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. 1986 Aug;53(2):264–266. doi: 10.1128/iai.53.2.264-266.1986

Monoclonal phosphorylcholine antibody binds to beta-lipoprotein from different animal species.

U B Sørensen
PMCID: PMC260868  PMID: 3733218

Abstract

Previously published observations have demonstrated that murine antibody with specificity for phosphorylcholine (PC) binds to a variety of PC-containing polysaccharides and to human beta-lipoprotein. In this investigation it was found that monoclonal anti-PC antibody binds not only to human beta-lipoprotein, but also to beta-lipoprotein from the serum of all vertebrate species examined. beta-Lipoprotein from mouse reacted with autologous antibody; therefore, this antibody must be an autoantibody. This raises the question whether PC antibodies may exert unwanted effects after having been passively transferred or induced by PC-containing antigens, e.g., C-polysaccharide from pneumococci.

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Selected References

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