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. 1986 Jun;52(3):905–907. doi: 10.1128/iai.52.3.905-907.1986

Protection of mice against lethal endotoxemia by a lipid A precursor.

R A Proctor, J A Will, K E Burhop, C R Raetz
PMCID: PMC260947  PMID: 3519466

Abstract

Lipid X, the major biosynthetic precursor of lipid A, has recently been described. Although lipid X is a mitogen and coagulates the Limulus amebocyte lysate, we found that it is not lethal for mice, even when given in large doses (2 X 10(6) micrograms/kg). Furthermore, lipid X was found to give partial protection against a 100% lethal dose of endotoxin, even if the lipid X was given as late as 6 h after endotoxin challenge.

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Selected References

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