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. 1980 Dec;72(12):1196–1199.

Metastatic Squamous Cell Carcinoma of the Skin

Hillard M Lazarus, Roger H Herzig, Richard Bornstein, Thomas C Laipply
PMCID: PMC2609730  PMID: 7310907

Abstract

Sunlight induced squamous cell carcinoma of the skin is common and produces low incidence of metastases. Non-actinic squamous cell carcinoma, however, possesses a metastatic potential even when well differentiated. A representative case of keratinizing squamous cell carcinoma arising in a lower extremity with development of widespread metastases is discussed. The prognostic factors associated with metastasizing de novo squamous cell carcinoma of the extremity include: site of origin, duration of lesion, degree of differentiation, sex of patient, and size of the primary lesion. Organs prone to metastasis include: regional lymph nodes, liver, lungs, and bone. As skin cancers of this variety metastasize, the clinician must recognize this potential when considering therapeutic strategy.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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