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. 1986 Mar;51(3):872–878. doi: 10.1128/iai.51.3.872-878.1986

Salmonella typhimurium virulence genes necessary to exploit the Itys/s genotype of the mouse.

W H Benjamin Jr, C L Turnbough Jr, B S Posey, D E Briles
PMCID: PMC260979  PMID: 3512437

Abstract

The studies described in this paper provide evidence that the pathogenesis of Salmonella typhimurium in mice is dependent on interactions between particular genotypes of the infected mice and the infecting Salmonella strain. This conclusion was based on data obtained by infecting a panel of BXD recombinant inbred mice with each of three S. typhimurium strains. One of the S. typhimurium strains was a transconjugant (WB500) produced in an interrupted mating between the two other strains, one (SR-11) of high and the other (LT2-Z) of low virulence for BALB/c mice. We found that strain WB500 appeared to have inherited from SR-11 a gene (or genes) which was required to exploit the Itys/s genotype in mice. However, WB500 apparently lacked other SR-11 virulence gene(s), whose effect on the in vivo growth of SR-11 was independent of the Ity genotype of the mouse.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benjamin W. H., Jr, Turnbough C. L., Jr, Posey B. S., Briles D. E. The ability of Salmonella typhimurium to produce the siderophore enterobactin is not a virulence factor in mouse typhoid. Infect Immun. 1985 Nov;50(2):392–397. doi: 10.1128/iai.50.2.392-397.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Briles D. E., Benjamin W. H., Jr, Williams C. A., Davie J. M. A genetic locus responsible for salmonella susceptibility in BSVS mice is not responsible for the limited T-dependent immune responsiveness of BSVS mice. J Immunol. 1981 Sep;127(3):906–911. [PubMed] [Google Scholar]
  3. Chumley F. G., Menzel R., Roth J. R. Hfr formation directed by tn10. Genetics. 1979 Apr;91(4):639–655. doi: 10.1093/genetics/91.4.639. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Duguid J. P. The function of bacterial fimbriae. Arch Immunol Ther Exp (Warsz) 1968;16(2):173–188. [PubMed] [Google Scholar]
  5. Eisenstein T. K., Deakins L. W., Killar L., Saluk P. H., Sultzer B. M. Dissociation of innate susceptibility to Salmonella infection and endotoxin responsiveness in C3HeB/FeJ mice and other strains in the C3H lineage. Infect Immun. 1982 May;36(2):696–703. doi: 10.1128/iai.36.2.696-703.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HOBSON D. The behaviour of a mutant strain of Salmonella typhimurium in experimental mouse typhoid. J Hyg (Lond) 1957 Sep;55(3):322–333. doi: 10.1017/s0022172400037232. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hoiseth S. K., Stocker B. A. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature. 1981 May 21;291(5812):238–239. doi: 10.1038/291238a0. [DOI] [PubMed] [Google Scholar]
  8. Hormaeche C. E. Natural resistance to Salmonella typhimurium in different inbred mouse strains. Immunology. 1979 Jun;37(2):311–318. [PMC free article] [PubMed] [Google Scholar]
  9. Hormaeche C. E. The in vivo division and death rates of Salmonella typhimurium in the spleens of naturally resistant and susceptible mice measured by the superinfecting phage technique of Meynell. Immunology. 1980 Dec;41(4):973–979. [PMC free article] [PubMed] [Google Scholar]
  10. Lissner C. R., Swanson R. N., O'Brien A. D. Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro. J Immunol. 1983 Dec;131(6):3006–3013. [PubMed] [Google Scholar]
  11. Mackaness G. B., Blanden R. V., Collins F. M. Host-parasite relations in mouse typhoid. J Exp Med. 1966 Oct 1;124(4):573–583. doi: 10.1084/jem.124.4.573. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Milne M., Collins F. M. Heat-labile antigens of Salmonella enteritidis. I. Extraction of antigens. J Bacteriol. 1966 Sep;92(3):543–548. doi: 10.1128/jb.92.3.543-548.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Nakano M., Saito K. Chemical components in the cell wall of Salmonella typhimurium affecting its virulence and immunogenicity in mice. Nature. 1969 Jun 14;222(5198):1085–1086. doi: 10.1038/2221085a0. [DOI] [PubMed] [Google Scholar]
  14. O'Brien A. D., Rosenstreich D. L., Scher I., Campbell G. H., MacDermott R. P., Formal S. B. Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene. J Immunol. 1980 Jan;124(1):20–24. [PubMed] [Google Scholar]
  15. O'Brien A. D., Rosenstreich D. L., Taylor B. A. Control of natural resistance to Salmonella typhimurium and Leishmania donovani in mice by closely linked but distinct genetic loci. Nature. 1980 Oct 2;287(5781):440–442. doi: 10.1038/287440a0. [DOI] [PubMed] [Google Scholar]
  16. O'Brien A. D., Scher I., Campbell G. H., MacDermott R. P., Formal S. B. Susceptibility of CBA/N mice to infection with Salmonella typhimurium: influence of the X-linked gene controlling B lymphocyte function. J Immunol. 1979 Aug;123(2):720–724. [PubMed] [Google Scholar]
  17. Plant J. E., Blackwell J. M., O'Brien A. D., Bradley D. J., Glynn A. A. Are the Lsh and Ity disease resistance genes at one locus on mouse chromosome 1? Nature. 1982 Jun 10;297(5866):510–511. doi: 10.1038/297510a0. [DOI] [PubMed] [Google Scholar]
  18. Plant J., Glynn A. A. Genetics of resistance to infection with Salmonella typhimurium in mice. J Infect Dis. 1976 Jan;133(1):72–78. doi: 10.1093/infdis/133.1.72. [DOI] [PubMed] [Google Scholar]
  19. Plant J., Glynn A. A. Locating salmonella resistance gene on mouse chromosome 1. Clin Exp Immunol. 1979 Jul;37(1):1–6. [PMC free article] [PubMed] [Google Scholar]
  20. Robson H. G., Vas S. I. Resistance of inbred mice to Salmonella typhimurium. J Infect Dis. 1972 Oct;126(4):378–386. doi: 10.1093/infdis/126.4.378. [DOI] [PubMed] [Google Scholar]
  21. SCHNEIDER H. A., ZINDER N. D. Nutrition of the host and natural resistance to infection. V. An improved assay employing genetic markers in the double strain inoculation test. J Exp Med. 1956 Feb 1;103(2):207–223. doi: 10.1084/jem.103.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Sanderson K. E., Roth J. R. Linkage map of Salmonella typhimurium, Edition VI. Microbiol Rev. 1983 Sep;47(3):410–453. doi: 10.1128/mr.47.3.410-453.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Tanaka Y., Katsube Y. Infectivity of Salmonella typhimurium for mice in relation to fimbriae. Nihon Juigaku Zasshi. 1978 Dec;40(6):671–681. doi: 10.1292/jvms1939.40.671. [DOI] [PubMed] [Google Scholar]
  24. Taylor B. A. Genetic analysis of susceptibility to isoniazid-induced seizures in mice. Genetics. 1976 Jun;83(2):373–377. doi: 10.1093/genetics/83.2.373. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. VOGEL H. J., BONNER D. M. Acetylornithinase of Escherichia coli: partial purification and some properties. J Biol Chem. 1956 Jan;218(1):97–106. [PubMed] [Google Scholar]
  26. Weinstein D. L., Carsiotis M., Lissner C. R., O'Brien A. D. Flagella help Salmonella typhimurium survive within murine macrophages. Infect Immun. 1984 Dec;46(3):819–825. doi: 10.1128/iai.46.3.819-825.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Yancey R. J., Breeding S. A., Lankford C. E. Enterochelin (enterobactin): virulence factor for Salmonella typhimurium. Infect Immun. 1979 Apr;24(1):174–180. doi: 10.1128/iai.24.1.174-180.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]

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