Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1986 Mar;51(3):961–963. doi: 10.1128/iai.51.3.961-963.1986

Protection against Brucella abortus in mice with O-polysaccharide-specific monoclonal antibodies.

J A Montaraz, A J Winter, D M Hunter, B A Sowa, A M Wu, L G Adams
PMCID: PMC260994  PMID: 3005173

Abstract

Mice injected with either of two monoclonal antibodies specific for the O polysaccharide of Brucella abortus prior to challenge infection had viable counts in spleens and livers significantly below those in control groups 1 and 4 weeks later. Two monoclonal antibodies specific for the porin of B. abortus failed to confer protection.

Full text

PDF
961

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BRAUDE A. I. Studies in the pathology and pathogenesis of experimental brucellosis. II. The formation of the hepatic granuloma and its evolution. J Infect Dis. 1951 Jul-Aug;89(1):87–94. doi: 10.1093/infdis/89.1.87. [DOI] [PubMed] [Google Scholar]
  2. Bascoul S., Cannat A., Huguet M. F., Serre A. Studies on the immune protection to murine experimental brucellosis conferred by Brucella fractions. I. Positive role of immune serum. Immunology. 1978 Aug;35(2):213–221. [PMC free article] [PubMed] [Google Scholar]
  3. Byrd J. W., Heck F. C., Hidalgo R. J. Evaluation of the enzyme-linked immunosorbent assay for detecting Brucella abortus antibodies. Am J Vet Res. 1979 Jun;40(6):896–898. [PubMed] [Google Scholar]
  4. Caroff M., Bundle D. R., Perry M. B., Cherwonogrodzky J. W., Duncan J. R. Antigenic S-type lipopolysaccharide of Brucella abortus 1119-3. Infect Immun. 1984 Nov;46(2):384–388. doi: 10.1128/iai.46.2.384-388.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cheers C. Pathogenesis and cellular immunity in experimental murine brucellosis. Dev Biol Stand. 1984;56:237–246. [PubMed] [Google Scholar]
  6. Colwell D. E., Michalek S. M., Briles D. E., Jirillo E., McGhee J. R. Monoclonal antibodies to Salmonella lipopolysaccharide: anti-O-polysaccharide antibodies protect C3H mice against challenge with virulent Salmonella typhimurium. J Immunol. 1984 Aug;133(2):950–957. [PubMed] [Google Scholar]
  7. Eisenstein T. K., Killar L. M., Sultzer B. M. Immunity to infection with Salmonella typhimurium: mouse-strain differences in vaccine- and serum-mediated protection. J Infect Dis. 1984 Sep;150(3):425–435. doi: 10.1093/infdis/150.3.425. [DOI] [PubMed] [Google Scholar]
  8. Hansen E. J., Robertson S. M., Gulig P. A., Frisch C. F., Haanes E. J. Immunoprotection of rats against Haemophilus influenzae type B disease mediated by monoclonal antibody against a haemophilus outer-membrane protein. Lancet. 1982 Feb 13;1(8268):366–368. doi: 10.1016/s0140-6736(82)91394-0. [DOI] [PubMed] [Google Scholar]
  9. Holman P. J., Adams L. G., Hunter D. M., Heck F. C., Nielsen K. H., Wagner G. G. Derivation of monoclonal antibodies against Brucella abortus antigens. Vet Immunol Immunopathol. 1983 Jul;4(5-6):603–614. doi: 10.1016/0165-2427(83)90068-5. [DOI] [PubMed] [Google Scholar]
  10. Kaneene J. M., Anderson R. K., Johnson D. W., Muscoplat C. C. Brucella antigen preparations for in vitro lymphocyte immunostimulation assays in bovine brucellosis. Infect Immun. 1978 Nov;22(2):486–491. doi: 10.1128/iai.22.2.486-491.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Kirkland T. N., Ziegler E. J. An immunoprotective monoclonal antibody to lipopolysaccharide. J Immunol. 1984 May;132(5):2590–2592. [PubMed] [Google Scholar]
  12. MACKANESS G. B. THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCE. J Exp Med. 1964 Jul 1;120:105–120. doi: 10.1084/jem.120.1.105. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Madraso E. D., Cheers C. Polyadenylic acid-polyuridylic acid (poly A : U) and experimental murine brucellosis. II. Macrophages as target cells of poly A : U in experimental brucellosis. Immunology. 1978 Jul;35(1):77–84. [PMC free article] [PubMed] [Google Scholar]
  14. Nielsen K. H., Rosenbaum B., Stiller J. M. Haemolysis in gel test for detecting bovine antibodies to Brucella abortus lipopolysaccharide. Res Vet Sci. 1983 Jan;34(1):68–72. [PubMed] [Google Scholar]
  15. Pardon P. Resistance against a subcutaneous Brucella challenge of mice immunized with living or dead Brucella or by transfer of immune serum. Ann Immunol (Paris) 1977 Nov-Dec;128(6):1025–1037. [PubMed] [Google Scholar]
  16. Pavlov H., Hogarth M., McKenzie I. F., Cheers C. In vivo and in vitro effects of monoclonal antibody to Ly antigens on immunity to infection. Cell Immunol. 1982 Jul 15;71(1):127–138. doi: 10.1016/0008-8749(82)90502-0. [DOI] [PubMed] [Google Scholar]
  17. Plommet M., Plommet A. M. Immune serum-mediated effects on brucellosis evolution in mice. Infect Immun. 1983 Jul;41(1):97–105. doi: 10.1128/iai.41.1.97-105.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. SULITZEANU D. Passive protection experiments with Brucella antisera. J Hyg (Lond) 1955 Jun;53(2):133–142. doi: 10.1017/s0022172400000619. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Sawada S., Suzuki M., Kawamura T., Fujinaga S., Masuho Y., Tomibe K. Protection against infection with Pseudomonas aeruginosa by passive transfer of monoclonal antibodies to lipopolysaccharides and outer membrane proteins. J Infect Dis. 1984 Oct;150(4):570–576. doi: 10.1093/infdis/150.4.570. [DOI] [PubMed] [Google Scholar]
  20. Verstreate D. R., Creasy M. T., Caveney N. T., Baldwin C. L., Blab M. W., Winter A. J. Outer membrane proteins of Brucella abortus: isolation and characterization. Infect Immun. 1982 Mar;35(3):979–989. doi: 10.1128/iai.35.3.979-989.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Wu A. M., Heck F. C., Adams L. G., Jones K. Immunochemical studies on the binding properties of Brucella abortus lipopolysaccharides to bovine precipitating antibodies. Mol Immunol. 1984 Nov;21(11):1123–1129. doi: 10.1016/0161-5890(84)90123-8. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES