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. 1986 May;52(2):529–533. doi: 10.1128/iai.52.2.529-533.1986

Recombination near the antibiotic resistance locus penB results in antigenic variation of gonococcal outer membrane protein I.

D Danielsson, H Faruki, D Dyer, P F Sparling
PMCID: PMC261032  PMID: 2422125

Abstract

In gonococci, the nonspecific antimicrobial resistance locus penB is known to be closely linked to loci designated nmp that alter the Mr and antigenicity of the outer membrane porin protein I (P.I). We report that after selection for the linked donor penB locus, occasional recombinants expressed P.I with some epitopes from each parent. These hybrid P.I antigens were stable on subculture and were transformed at a locus closely linked to penB. The hybrid P.I antigens were detected with monoclonal antibodies in both coagglutination and Western blot assays. The alterations of P.I antigenicity may have resulted from recombination between structural genes for P.I that are closely linked to penB.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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