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. 1986 May;52(2):623–627. doi: 10.1128/iai.52.2.623-627.1986

Immunohistochemical distribution of ferritin, lactoferrin, and transferrin in granulomas of bovine paratuberculosis.

E Momotani, K Furugouri, Y Obara, Y Miyata, Y Ishikawa, T Yoshino
PMCID: PMC261048  PMID: 3699898

Abstract

Granulomatous lesions of bovine paratuberculosis contained ferritin, lactoferrin, and a small amount of transferrin, as demonstrated by the immunohistochemical method. Macrophages in the normal bovine ileum did not contain lactoferrin and transferrin; however, ferritin was found in individual macrophages of Peyer's patches. These results may help elucidate the relationship between intracellular growth of Mycobacterium paratuberculosis and the presence of iron-binding proteins in the granulomas.

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Selected References

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