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. 1986 Jan;51(1):365–368. doi: 10.1128/iai.51.1.365-368.1986

Transfer of resistance to syphilitic infection from maternal to newborn guinea pigs.

C S Pavia
PMCID: PMC261114  PMID: 3510176

Abstract

Partial protection against cutaneous syphilis and dissemination of treponemes to the regional lymph nodes was achievable in Treponema pallidum-infected neonatal strain 2 guinea pigs having syphilis-immune mothers. This evidence for enhanced resistance was associated with the natural transfer of antitreponemal, maternally derived immunoglobulins before parturition.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARNES J. M. Antitoxin transfer from mother to foetus in the guinea-pig. J Pathol Bacteriol. 1959 Apr;77(2):371–380. doi: 10.1002/path.1700770206. [DOI] [PubMed] [Google Scholar]
  2. Beer A. E., Billingham R. E. Maternally acquired runt disease. Science. 1973 Jan 19;179(4070):240–243. doi: 10.1126/science.179.4070.240. [DOI] [PubMed] [Google Scholar]
  3. Bishop N. H., Miller J. N. Humoral immunity in experimental syphilis. I. The demonstration of resistance conferred by passive immunization. J Immunol. 1976 Jul;117(1):191–196. [PubMed] [Google Scholar]
  4. Gamboa D., Miller J. N. Experimental neonatal syphilis. I. Evidence of resistance to symptomatic infection in neonatal rabbits following intradermal inoculation with Treponema pallidum (Nichols strain). Pediatr Res. 1984 Oct;18(10):965–971. doi: 10.1203/00006450-198410000-00012. [DOI] [PubMed] [Google Scholar]
  5. JO K. On the transmission of antibodies from mothers to their offsprings in experimental typhus fever, experiments in albino rats and guinea pigs. Jpn J Med Sci Biol. 1953 Jun;6(3):299–300. doi: 10.7883/yoken1952.6.299. [DOI] [PubMed] [Google Scholar]
  6. Pavia C. S., Folds J. D., Baseman J. B. Selective in vitro response of thymus-derived lymphocytes from Treponema pallidum-infected rabbits. Infect Immun. 1977 Dec;18(3):603–611. doi: 10.1128/iai.18.3.603-611.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Pavia C. S., Niederbuhl C. J. Acquired resistance and expression of a protective humoral immune response in guinea pigs infected with Treponema pallidum Nichols. Infect Immun. 1985 Oct;50(1):66–72. doi: 10.1128/iai.50.1.66-72.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Pavia C. S., Niederbuhl C. J. Adoptive transfer of anti-syphilis immunity with lymphocytes from Treponema pallidum-infected guinea pigs. J Immunol. 1985 Oct;135(4):2829–2834. [PubMed] [Google Scholar]
  9. Pavia C. S., Niederbuhl C. J. Experimental infection of inbred guinea pigs with Treponema pallidum: development of lesions and formation of antibodies. Genitourin Med. 1985 Apr;61(2):75–81. doi: 10.1136/sti.61.2.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pavia C. S., Niederbuhl C. J., Saunders J. Antibody-mediated protection of guinea-pigs against infection with Treponema pallidum. Immunology. 1985 Oct;56(2):195–202. [PMC free article] [PubMed] [Google Scholar]
  11. SELL S. EVIDENCE FOR SPECIES' DIFFERENCES IN THE EFFECT OF SERUM GAMMA-GLOBULIN CONCENTRATION ON GAMMA-GLOBULIN CATABOLISM. J Exp Med. 1964 Nov 1;120:967–986. doi: 10.1084/jem.120.5.967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Titus R. G., Weiser R. S. Experimental syphilis in the rabbit: passive transfer of immunity with immunoglobulin G from immune serum. J Infect Dis. 1979 Dec;140(6):904–913. doi: 10.1093/infdis/140.6.904. [DOI] [PubMed] [Google Scholar]
  13. Turner T. B., Hardy P. H., Jr, Newman B., Nell E. E. Effects of passive immunization on experimental syphilis in the rabbit. Johns Hopkins Med J. 1973 Nov;133(5):241–251. [PubMed] [Google Scholar]
  14. Weiser R. S., Erickson D., Perine P. L., Pearsall N. N. Immunity to syphilis: passive transfer in rabbits using serial doses of immune serum. Infect Immun. 1976 May;13(5):1402–1407. doi: 10.1128/iai.13.5.1402-1407.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]

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