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. 1985 Dec;50(3):925–928. doi: 10.1128/iai.50.3.925-928.1985

Enteroadhesion fimbriae and enterotoxin of Escherichia coli: genetic transfer to a streptomycin-resistant mutant of the galE oral-route live-vaccine Salmonella typhi Ty21a.

T Yamamoto, Y Tamura, T Yokota
PMCID: PMC261171  PMID: 3905619

Abstract

An enterotoxigenic Escherichia coli plasmid encoding colonization factor antigen (CFA) I fimbriae and heat-stable toxin was transferred into a streptomycin-resistant mutant of the Salmonella typhi galE strain Ty21a (a live attenuated oral typhoid vaccine). The virulence plasmid-carrying transconjugants produced CFA I fimbriae and heat-stable toxin. The marked production of CFA I fimbriae was observed even in a vaccine medium for Ty21a. The data lead to a new type of potential live oral vaccine, S. typhi Ty21a producing enteroadhesion fimbriae.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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