Abstract
Congenitally athymic nude mice and their heterozygous counterparts were inoculated intravaginally with the chlamydial agent of mouse pneumonitis, a Chlamydia trachomatis biovar. Heterozygous mice resolved their infections in 20 days, whereas nude mice developed chronic infections which lasted at least 265 days and did not resolve within the time course of the experiments. Heterozygous mice produced high levels of antibody in both serum and secretions in contrast to nude mice, which produced very low levels of antibody in serum alone.
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Selected References
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- Barron A. L., Rank R. G., Moses E. B. Immune response in mice infected in the genital tract with mouse pneumonitis agent (Chlamydia trachomatis biovar). Infect Immun. 1984 Apr;44(1):82–85. doi: 10.1128/iai.44.1.82-85.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barron A. L., White H. J., Rank R. G., Soloff B. L., Moses E. B. A new animal model for the study of Chlamydia trachomatis genital infections: infection of mice with the agent of mouse pneumonitis. J Infect Dis. 1981 Jan;143(1):63–66. doi: 10.1093/infdis/143.1.63. [DOI] [PubMed] [Google Scholar]
- Corley R. B. The regulation of T cell growth: requirements for the activation and replication of antigen-specific interleukin 2 producing T cells. Immunobiology. 1982 Oct;163(1):63–76. doi: 10.1016/s0171-2985(82)80107-1. [DOI] [PubMed] [Google Scholar]
- Gillis S., Ferm M. M., Ou W., Smith K. A. T cell growth factor: parameters of production and a quantitative microassay for activity. J Immunol. 1978 Jun;120(6):2027–2032. [PubMed] [Google Scholar]
- Klein J. R., Bevan M. J. Secretion of immune interferon and generation of cytotoxic T cell activity in nude mice are dependent on interleukin 2: age-associated endogenous production of interleukin 2 in nude mice. J Immunol. 1983 Apr;130(4):1780–1783. [PubMed] [Google Scholar]
- Rank R. G., Barron A. L. Effect of antithymocyte serum on the course of chlamydial genital infection in female guinea pigs. Infect Immun. 1983 Aug;41(2):876–879. doi: 10.1128/iai.41.2.876-879.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rank R. G., White H. J., Barron A. L. Humoral immunity in the resolution of genital infection in female guinea pigs infected with the agent of guinea pig inclusion conjunctivitis. Infect Immun. 1979 Nov;26(2):573–579. doi: 10.1128/iai.26.2.573-579.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Soderberg L. S., Yeh N. H. Fetal calf serum and 2-mercaptoethanol induce anti-trinitrophenyl antibody production: II. Preferential stimulation of B cells in culture. J Biol Response Mod. 1983;2(3):263–271. [PubMed] [Google Scholar]
- Tuffrey M., Falder P., Taylor-Robinson D. Genital-tract infection and disease in nude and immunologically competent mice after inoculation of a human strain of Chlamydia trachomatis. Br J Exp Pathol. 1982 Oct;63(5):539–546. [PMC free article] [PubMed] [Google Scholar]
- Williams D. M., Schachter J., Coalson J. J., Grubbs B. Cellular immunity to the mouse pneumonitis agent. J Infect Dis. 1984 Apr;149(4):630–639. doi: 10.1093/infdis/149.4.630. [DOI] [PubMed] [Google Scholar]
- Williams D. M., Schachter J., Grubbs B., Sumaya C. V. The role of antibody in host defense against the agent of mouse pneumonitis. J Infect Dis. 1982 Feb;145(2):200–205. doi: 10.1093/infdis/145.2.200. [DOI] [PubMed] [Google Scholar]
- Williams D. M., Schachter J., Weiner M. H., Grubbs B. Antibody in host defense against mouse pneumonitis agent (murine Chlamydia trachomatis). Infect Immun. 1984 Sep;45(3):674–678. doi: 10.1128/iai.45.3.674-678.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]