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. 1985 Mar;47(3):719–722. doi: 10.1128/iai.47.3.719-722.1985

Interferon-induced inhibition of Chlamydia trachomatis: dissociation from antiviral and antiproliferative effects.

L M de la Maza, E M Peterson, J M Goebel, C W Fennie, C W Czarniecki
PMCID: PMC261369  PMID: 3972450

Abstract

The yield of infectious Chlamydia trachomatis was analyzed in human (HeLa) and mouse (McCoy) cell lines treated with the human interferon (IFN) subtypes IFN-alpha A and IFN-alpha D, with their hybrids [IFN-alpha AD (BglII), IFN-alpha AD (PvuII), and IFN-alpha DA (BglII)] constructed in vitro from their expression plasmids, or with IFN-beta 1 or buffy coat IFN. In HeLa cells, a significant inhibition of Chlamydia infectivity was obtained with IFN-alpha D, IFN-alpha DA (BglII), and buffy coat IFN. In McCoy cells, IFN-alpha AD (BglII) and IFN-alpha AD (PvuII) induced a strong degree of inhibition of Chlamydia infectivity. In McCoy cells, there was a correlation among the antichlamydial, antiviral, and antiproliferative activities of the different IFNs tested. In HeLa cells, however, the ability of a particular IFN subtype to inhibit Chlamydia infectivity did not always correlate with its inhibitory effects on encephalomyocarditis virus replication or with its antiproliferative activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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