Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1985 May;48(2):581–583. doi: 10.1128/iai.48.2.581-583.1985

Augmentation of interleukin-2 production and delayed hypersensitivity in mice infected with Mycobacterium bovis and fed a diet supplemented with vitamin A acetate.

V Colizzi, M Malkovsky
PMCID: PMC261387  PMID: 3886551

Abstract

High-dose Mycobacterium bovis-infected mice fed a vitamin A acetate-supplemented diet developed a positive skin reaction to purified protein derivative of mycobacteria, and their spleen cells showed an increased IL-2 production in vitro.

Full text

PDF
581

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cohen B. E., Elin R. J. Vitamin A-induced nonspecific resistance to infection. J Infect Dis. 1974 May;129(5):597–600. doi: 10.1093/infdis/129.5.597. [DOI] [PubMed] [Google Scholar]
  2. Colizzi V., Ferluga J., Garreau F., Malkovsky M., Asherson G. L. Suppressor cells induced by BCG release non-specific factors in vitro which inhibit DNA synthesis and interleukin-2 production. Immunology. 1984 Jan;51(1):65–71. [PMC free article] [PubMed] [Google Scholar]
  3. Colizzi V. In vivo and in vitro administration of interleukin 2-containing preparation reverses T-cell unresponsiveness in Mycobacterium bovis BCG-infected mice. Infect Immun. 1984 Jul;45(1):25–28. doi: 10.1128/iai.45.1.25-28.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Haregewoin A., Godal T., Mustafa A. S., Belehu A., Yemaneberhan T. T-cell conditioned media reverse T-cell unresponsiveness in lepromatous leprosy. Nature. 1983 May 26;303(5915):342–344. doi: 10.1038/303342a0. [DOI] [PubMed] [Google Scholar]
  5. Hof H., Emmerling P. Stimulation of cell-mediated resistance in mice to infection with Listeria monocytogenes by vitamin A. Ann Immunol (Paris) 1979 Jul-Aug;130C(4):587–594. [PubMed] [Google Scholar]
  6. Hoffenbach A., Lagrange P. H., Bach M. A. Deficit of interleukin 2 production associated with impaired T-cell proliferative responses in Mycobacterium lepraemurium infection. Infect Immun. 1983 Jan;39(1):109–116. doi: 10.1128/iai.39.1.109-116.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Malkovsky M., Asherson G. L., Stockinger B., Watkins M. C. Nonspecific inhibitor released by T acceptor cells reduces the production of interleukin-2. Nature. 1982 Dec 16;300(5893):652–655. doi: 10.1038/300652a0. [DOI] [PubMed] [Google Scholar]
  8. Malkovský M., Doré C., Hunt R., Palmer L., Chandler P., Medawar P. B. Enhancement of specific antitumor immunity in mice fed a diet enriched in vitamin A acetate. Proc Natl Acad Sci U S A. 1983 Oct;80(20):6322–6326. doi: 10.1073/pnas.80.20.6322. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Malkovský M., Edwards A. J., Hunt R., Palmer L., Medawar P. B. T-cell-mediated enhancement of host-versus-graft reactivity in mice fed a diet enriched in vitamin A acetate. Nature. 1983 Mar 24;302(5906):338–340. doi: 10.1038/302338a0. [DOI] [PubMed] [Google Scholar]
  10. Malkovský M., Medawar P. B., Thatcher D. R., Toy J., Hunt R., Rayfield L. S., Doré C. Acquired immunological tolerance of foreign cells is impaired by recombinant interleukin 2 or vitamin A acetate. Proc Natl Acad Sci U S A. 1985 Jan;82(2):536–538. doi: 10.1073/pnas.82.2.536. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Malkovský M., Medawar P., Hunt R., Palmer L., Doré C. A diet enriched in vitamin A acetate or in vivo administration of interleukin-2 can counteract a tolerogenic stimulus. Proc R Soc Lond B Biol Sci. 1984 Feb 22;220(1221):439–445. doi: 10.1098/rspb.1984.0012. [DOI] [PubMed] [Google Scholar]
  12. Turcotte R. Evidence for two distinct populations of suppressor cells in the spleens of Mycobacterium bovis BCG-Sensitized mice. Infect Immun. 1981 Nov;34(2):315–322. doi: 10.1128/iai.34.2.315-322.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES