Abstract
Treatment of HEp-2 cell cultures with highly purified human gamma interferon before infection resulted in the reduction of Chlamydia trachomatis (L2/434/Bu) infectious particle yield. Electron microscope studies showed that interferon did not affect chlamydial conversion to reticulate bodies but influenced the extent of maturation to elementary bodies. High interferon concentrations (greater than 350 IU/ml) inhibited inclusion body formation and resulted in the appearance of aberrant reticulate bodies.
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- Byrne G. I., Krueger D. A. Lymphokine-mediated inhibition of Chlamydia replication in mouse fibroblasts is neutralized by anti-gamma interferon immunoglobulin. Infect Immun. 1983 Dec;42(3):1152–1158. doi: 10.1128/iai.42.3.1152-1158.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Caldwell H. D., Kromhout J., Schachter J. Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis. Infect Immun. 1981 Mar;31(3):1161–1176. doi: 10.1128/iai.31.3.1161-1176.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Friis R. R. Interaction of L cells and Chlamydia psittaci: entry of the parasite and host responses to its development. J Bacteriol. 1972 May;110(2):706–721. doi: 10.1128/jb.110.2.706-721.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HIGASHI N. ELECTRON MICROSCOPIC STUDIES ON THE MODE OF REPRODUCTION OF TRACHOMA VIRUS AND PSITTACOSIS VIRUS IN CELL CULTURES. Exp Mol Pathol. 1965 Feb;76:24–39. doi: 10.1016/0014-4800(65)90021-3. [DOI] [PubMed] [Google Scholar]
- Haikin H., Sarov I. Determination of specific IGA antibodies to varicella zoster virus by immunoperoxidase assay. J Clin Pathol. 1982 Jun;35(6):645–649. doi: 10.1136/jcp.35.6.645. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Henry-Suchet J., Catalan F., Loffredo V., Sanson M. J., Debache C., Pigeau F., Coppin R. Chlamydia trachomatis associated with chronic inflammation in abdominal specimens from women selected for tuboplasty. Fertil Steril. 1981 Nov;36(5):599–605. doi: 10.1016/s0015-0282(16)45857-7. [DOI] [PubMed] [Google Scholar]
- Kellogg K. R., Horoschak K. D., Moulder J. W. Toxicity of low and moderate multiplicities of Chlamydia psittaci for mouse fibroblasts (L cells). Infect Immun. 1977 Nov;18(2):531–541. doi: 10.1128/iai.18.2.531-541.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LITWIN J. The growth cycle of the psittacosis group of micro-organisms. J Infect Dis. 1959 Sep-Oct;105:129–160. doi: 10.1093/infdis/105.2.129. [DOI] [PubMed] [Google Scholar]
- Rothermel C. D., Byrne G. I., Havell E. A. Effect of interferon on the growth of Chlamydia trachomatis in mouse fibroblasts (L cells). Infect Immun. 1983 Jan;39(1):362–370. doi: 10.1128/iai.39.1.362-370.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rothermel C. D., Rubin B. Y., Murray H. W. Gamma-interferon is the factor in lymphokine that activates human macrophages to inhibit intracellular Chlamydia psittaci replication. J Immunol. 1983 Nov;131(5):2542–2544. [PubMed] [Google Scholar]
- Sarov I., Becker Y. RNA in the elementary bodies of trachoma agent. Nature. 1968 Mar 2;217(5131):849–852. doi: 10.1038/217849b0. [DOI] [PubMed] [Google Scholar]
- Sarov I., Becker Y. Trachoma agent DNA. J Mol Biol. 1969 Jun 28;42(3):581–589. doi: 10.1016/0022-2836(69)90245-9. [DOI] [PubMed] [Google Scholar]
- Sueltenfuss E. A., Pollard M. Cytochemical Assay of Interferon Produced by Duck Hepatitis Virus. Science. 1963 Feb 15;139(3555):595–596. doi: 10.1126/science.139.3555.595. [DOI] [PubMed] [Google Scholar]
- Weiss E. Adenosine Triphosphate and Other Requirements for the Utilization of Glucose by Agents of the Psittacosis-Trachoma Group. J Bacteriol. 1965 Jul;90(1):243–253. doi: 10.1128/jb.90.1.243-253.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]