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. 1985 May;48(2):597–600. doi: 10.1128/iai.48.2.597-600.1985

Binding activity of a murine anti-lipid A monoclonal antibody.

K Elkins, E S Metcalf
PMCID: PMC261394  PMID: 2580797

Abstract

In this report we briefly describe an immunoglobulin G3 monoclonal antibody, 2G6/1H11, which binds purified lipid A from Salmonella minnesota and a lipid A precursor molecule derived from Salmonella typhimurium. 2G6/1H11 does not bind well to purified whole S. typhimurium lipopolysaccharide (LPS), S. minnesota LPS, LPS preparations from a series of S. minnesota rough mutants, or intact S. typhimurium bacteria. Thus, there are antigenic determinants in purified lipid A which are not exposed when lipid A is presented as part of the whole LPS molecule or intact bacteria.

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Selected References

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