Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1984 Dec;46(3):668–672. doi: 10.1128/iai.46.3.668-672.1984

A role for rheumatoid factor enhancement of Plasmodium falciparum schizont inhibition in vitro.

T J Green, B J Packer
PMCID: PMC261594  PMID: 6389357

Abstract

Studies were undertaken to determine whether rheumatoid factor (RF) was present in immune human and Aotus trivirgatus monkey sera which inhibited Plasmodium falciparum schizonts in vitro and to determine whether RF could be responsible for or contribute to merozoite agglutination in the parasite inhibition test. Additional studies were conducted to determine the effect of exogenous RF on schizont inhibition when used alone or in conjunction with immune or normal sera. RF was not detected in any of the 11 immune monkey sera or the 3 immune human sera which were tested. However, when RF was added to immune human or Aotus sera, levels of schizont inhibition increased significantly over levels obtained with immune serum alone. When RF was used alone or in conjunction with normal sera, levels of schizont inhibition were comparable to those obtained with normal serum. Furthermore, adsorption of the RF with immunoglobulin G-coated erythrocytes removed the enhancing activity. The results of this study indicate that RF, which is sometimes produced during acute or chronic malarial infection, may contribute nonspecifically to the enhanced clearance of plasmodia in vivo.

Full text

PDF
668

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABELE D. C., TOBIE J. E., HILL G. J., CONTACOS P. G., EVANS C. B. ALTERATIONS IN SERUM PROTEINS AND 19S ANTIBODY PRODUCTION DURING THE COURSE OF INDUCED MALARIAL INFECTIONS IN MAN. Am J Trop Med Hyg. 1965 Mar;14:191–197. doi: 10.4269/ajtmh.1965.14.191. [DOI] [PubMed] [Google Scholar]
  2. Bolton W. K., Schrock J. H., Davis J. S., 4th Rheumatoid factor inhibition of in vitro binding of IgG complexes in the human glomerulus. Arthritis Rheum. 1982 Mar;25(3):297–303. doi: 10.1002/art.1780250307. [DOI] [PubMed] [Google Scholar]
  3. Cabral H. R. Rheumatoid factors and Chagas' disease. Science. 1983 Mar 11;219(4589):1238–1238. doi: 10.1126/science.10896571. [DOI] [PubMed] [Google Scholar]
  4. Campbell G. H., Mrema J. E., O'Leary T. R., Jost R. C., Rieckmann K. H. In vitro inhibition of the growth of Plasmodium falciparum by Aotus serum. Bull World Health Organ. 1979;57 (Suppl 1):219–225. [PMC free article] [PubMed] [Google Scholar]
  5. Carson D. A., Bayer A. S., Eisenberg R. A., Lawrance S., Theofilopoulos A. IgG rheumatoid factor in subacute bacterial endocarditis: relationship to IgM rheumatoid factor and circulating immune complexes. Clin Exp Immunol. 1978 Jan;31(1):100–103. [PMC free article] [PubMed] [Google Scholar]
  6. Carvalho E. M., Andrews B. S., Martinelli R., Dutra M., Rocha H. Circulating immune complexes and rheumatoid factor in schistosomiasis and visceral leishmaniasis. Am J Trop Med Hyg. 1983 Jan;32(1):61–68. doi: 10.4269/ajtmh.1983.32.61. [DOI] [PubMed] [Google Scholar]
  7. Clarkson A. B., Jr, Mellow G. H. Rheumatoid factor-like immunoglobulin M protects previously uninfected rat pups and dams from Trypanosoma lewisi. Science. 1981 Oct 9;214(4517):186–188. doi: 10.1126/science.7025211. [DOI] [PubMed] [Google Scholar]
  8. Clarkson A. B., Jr, Mellow G. H. Rheumatoid factors and Chagas' disease. Science. 1983 Mar 11;219(4589):1238–1239. doi: 10.1126/science.6402816. [DOI] [PubMed] [Google Scholar]
  9. Cohen S., Butcher G. A., Crandall R. B. Action of malarial antibody in vitro. Nature. 1969 Jul 26;223(5204):368–371. doi: 10.1038/223368a0. [DOI] [PubMed] [Google Scholar]
  10. Collins W. E., Contacos P. G., Skinner J. C., Harrison A. J., Gell L. S. Patterns of antibody and serum proteins in experimentally induced human malaria. Trans R Soc Trop Med Hyg. 1971;65(1):43–58. doi: 10.1016/0035-9203(71)90184-2. [DOI] [PubMed] [Google Scholar]
  11. DRESNER E., TROMBLY P. The latex-fixation reaction in nonrheumatic diseases. N Engl J Med. 1959 Nov 12;261:981–988. doi: 10.1056/NEJM195911122612001. [DOI] [PubMed] [Google Scholar]
  12. Dresser D. W. Most IgM-producing cells in the mouse secrete auto-antibodies (rheumatoid factor). Nature. 1978 Aug 3;274(5670):480–483. doi: 10.1038/274480a0. [DOI] [PubMed] [Google Scholar]
  13. Green T. J., Morhardt M., Brackett R. G., Jacobs R. L. Serum inhibition of merozoite dispersal from Plasmodium falciparum schizonts: indicator of immune status. Infect Immun. 1981 Mar;31(3):1203–1208. doi: 10.1128/iai.31.3.1203-1208.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Jayawardena A. N., Janeway C. A., Jr, Kemp J. D. Experimental malaria in the CBA/N mouse. J Immunol. 1979 Dec;123(6):2532–2539. [PubMed] [Google Scholar]
  15. Jeje O. M., Kelton J. G., Blajchman M. A. Quantitation of red cell membrane associated immunoglobulin in children with Plasmodium falciparum parasitaemia. Br J Haematol. 1983 Aug;54(4):567–572. doi: 10.1111/j.1365-2141.1983.tb02135.x. [DOI] [PubMed] [Google Scholar]
  16. KOHN J. A micro-electrophoretic method. Nature. 1958 Mar 22;181(4612):839–840. doi: 10.1038/181839a0. [DOI] [PubMed] [Google Scholar]
  17. KUVIN S. F., TOBIE J. E., EVANS C. B., COATNEY G. R., CONTACOS P. G. Fluorescent antibody studies on the course of antibody production and serum gamma globulin levels in normal volunteers infected with human and simian malaria. Am J Trop Med Hyg. 1962 Jul;11:429–436. doi: 10.4269/ajtmh.1962.11.429. [DOI] [PubMed] [Google Scholar]
  18. Kay M. M. Mechanism of removal of senescent cells by human macrophages in situ. Proc Natl Acad Sci U S A. 1975 Sep;72(9):3521–3525. doi: 10.1073/pnas.72.9.3521. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Kreier J. P. Mechanisms of erythrocyte destruction in chickens infected with Plasmodium gallinaceum. Mil Med. 1969 Sep;134(10):1203–1219. [PubMed] [Google Scholar]
  20. Kreier J. P. Mechanisms of erythrocyte destruction in chickens infected with Plasmodium gallinaceum. Mil Med. 1969 Sep;134(10):1203–1219. [PubMed] [Google Scholar]
  21. Kreier J., Shapiro H., Dilley D., Szilvassy I. P., Ristic M. Autoimmune reactions in rats with Plasmodium berghei infection. Exp Parasitol. 1966 Oct;19(2):155–162. doi: 10.1016/0014-4894(66)90064-6. [DOI] [PubMed] [Google Scholar]
  22. Lambros C., Vanderberg J. P. Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol. 1979 Jun;65(3):418–420. [PubMed] [Google Scholar]
  23. Lustig H. J., Nussenzweig V., Nussenzweig R. S. Erythrocyte membrane-associated immunoglobulins during malaria infection of mice. J Immunol. 1977 Jul;119(1):210–216. [PubMed] [Google Scholar]
  24. Nasir M. M., Ghatak S. Effect of different reagents on lysis of Salmonella typhosa. Indian J Med Res. 1970 Jan;58(1):1–10. [PubMed] [Google Scholar]
  25. Phillips R. S., Trigg P. I., Scott-Finnigan T. J., Bartholomew R. K. Culture of Plasmodium falciparum in vitro: a subculture technique used for demonstrating antiplasmodial activity in serum from some Gambians, resident in an endemic malarious area. Parasitology. 1972 Dec;65(3):525–535. doi: 10.1017/s0031182000044139. [DOI] [PubMed] [Google Scholar]
  26. Reese R. T., Motyl M. R. Inhibition of the in vitro growth of Plasmodium falciparum. I. The effects of immune serum and purified immunoglobulin from owl monkeys. J Immunol. 1979 Oct;123(4):1894–1899. [PubMed] [Google Scholar]
  27. Shear H. L., Nussenzweig R. S., Bianco C. Immune phagocytosis in murine malaria. J Exp Med. 1979 Jun 1;149(6):1288–1298. doi: 10.1084/jem.149.6.1288. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Trager W., Jensen J. B. Human malaria parasites in continuous culture. Science. 1976 Aug 20;193(4254):673–675. doi: 10.1126/science.781840. [DOI] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES