Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1985 Apr;48(1):1–6. doi: 10.1128/iai.48.1.1-6.1985

Cyclic development of immunological memory to bacterial lipopolysaccharide.

P J Baker, J R Hiernaux, P W Stashak, J A Rudbach
PMCID: PMC261904  PMID: 3884505

Abstract

Immunological memory to the lipopolysaccharide of Escherichia coli O113 was generated in strains of inbred mice given a single subimmunogenic dose of either E. coli O113 lipopolysaccharide or the native protoplasmic polysaccharide of E. coli O113. Such memory, which only involved antibody of the immunoglobulin M class, developed in a cyclic manner that was characteristic for the strain of mice used. It involved cell proliferation as well as differentiation and persisted for at least 25 days after priming with a single injection of a subimmunogenic dose of E. coli O113 lipopolysaccharide.

Full text

PDF
1

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANACKER R. L., FINKELSTEIN R. A., HASKINS W. T., LANDY M., MILNER K. C., RIBI E., STASHAK P. W. ORIGIN AND PROPERTIES OF NATURALLY OCCURRING HAPTEN FROM ESCHERICHIA COLI. J Bacteriol. 1964 Dec;88:1705–1720. doi: 10.1128/jb.88.6.1705-1720.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Anacker R. L., Bickel W. D., Haskins W. T., Milner K. C., Ribi E., Rudbach J. A. Frequency of occurrence of native hapten among enterobacterial species. J Bacteriol. 1966 Apr;91(4):1427–1433. doi: 10.1128/jb.91.4.1427-1433.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Braley-Mullen H. Antigen requirements for induction of B-memory cells: studies with dinitrophenyl coupled to T-dependent and T-independent carriers. J Exp Med. 1978 Jun 1;147(6):1824–1831. doi: 10.1084/jem.147.6.1824. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Brooks K. H., Feldbush T. L. Generation of antibody-mediated regulation during in vitro clonal expansion of memory B lymphocytes. J Immunol. 1981 Sep;127(3):963–967. [PubMed] [Google Scholar]
  5. Brooks K. H., Feldbush T. L. In vitro antigen-mediated clonal expansion of memory B lymphocytes. J Immunol. 1981 Sep;127(3):959–963. [PubMed] [Google Scholar]
  6. Brooks K. H., Feldbush T. L., van der Hoven A. The generation of memory B-cell subpopulations capable of proliferation and expansion of the pool: effect of time and antigen. Cell Immunol. 1980 Mar 15;50(2):392–404. doi: 10.1016/0008-8749(80)90293-2. [DOI] [PubMed] [Google Scholar]
  7. Celada F. The cellular basis of immunologic memory. Prog Allergy. 1971;15:223–267. [PubMed] [Google Scholar]
  8. Chiller J. M., Weigle W. O. Termination of tolerance to human gamma globulin in mice by antigen and bacterial lipopolysaccharide (endotoxin). J Exp Med. 1973 Mar 1;137(3):740–750. doi: 10.1084/jem.137.3.740. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Colle J. H., Motta I., Shidani B., Truffa-Bachi P. Igh-V or closely linked gene(s) control immunological memory to a thymus-independent antigen. Nature. 1983 Feb 3;301(5899):428–429. doi: 10.1038/301428a0. [DOI] [PubMed] [Google Scholar]
  10. Dresser D. W., Popham A. M. The influence of T cells on the initiation and expression of immunological memory. Immunology. 1979 Oct;38(2):265–274. [PMC free article] [PubMed] [Google Scholar]
  11. Gottlieb C. F. Application of transformations to normalize the distribution of plaque-forming cells. J Immunol. 1974 Jul;113(1):51–57. [PubMed] [Google Scholar]
  12. Hiernaux J. R., Baker P. J., Delisi C., Rudbach J. A. Modulation of the immune response to lipopolysaccharide. J Immunol. 1982 Mar;128(3):1054–1058. [PubMed] [Google Scholar]
  13. Hiernaux J. R., Jones J. M., Rudbach J. A., Rollwagen F., Baker P. J. Antibody response of immunodeficient (xid) CBA/N mice to Escherichia coli 0113 lipopolysaccharide, a thymus-independent antigen. J Exp Med. 1983 Apr 1;157(4):1197–1207. doi: 10.1084/jem.157.4.1197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hosokawa T. Studies on B-cell memory. II. T-cell independent antigen can induce B-cell memory. Immunology. 1979 Oct;38(2):291–299. [PMC free article] [PubMed] [Google Scholar]
  15. Hünig T., Schimpl A., Wecker E. Autoradiographic studies on the proliferation of antibody-producing cells in vitro. J Exp Med. 1974 Mar 1;139(3):754–760. doi: 10.1084/jem.139.3.754. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Macario A. J., Conway de Macario E. Silent generation of memory in genetic low-responder mice after a single contract with a bacterial antigen. Cell Immunol. 1978 Apr;37(1):263–267. doi: 10.1016/0008-8749(78)90193-4. [DOI] [PubMed] [Google Scholar]
  17. Mitchison N. A. The carrier effect in the secondary response to hapten-protein conjugates. I. Measurement of the effect with transferred cells and objections to the local environment hypothesis. Eur J Immunol. 1971 Jan;1(1):10–17. doi: 10.1002/eji.1830010103. [DOI] [PubMed] [Google Scholar]
  18. Nossal G. J., Austin C. M., Ada G. L. Antigens in immunity. VII. Analysis of immunological memory. Immunology. 1965 Oct;9(4):333–348. [PMC free article] [PubMed] [Google Scholar]
  19. Perkins E. H., Sado T., Makinodan T. Recruitment and proliferation of immunocompetent cells during the log phase of the primary antibody response. J Immunol. 1969 Oct;103(4):668–678. [PubMed] [Google Scholar]
  20. Roelants G. E., Askonas B. A. Immunological B memory in thymus deprived mice. Nat New Biol. 1972 Sep 13;239(89):63–64. doi: 10.1038/newbio239063a0. [DOI] [PubMed] [Google Scholar]
  21. Rudbach J. A., Akiya F. I., Elin R. J., Hochstein H. D., Luoma M. K., Milner E. C., Milner K. C., Thomas K. R. Preparation and properties of a national reference endotoxin. J Clin Microbiol. 1976 Jan;3(1):21–25. doi: 10.1128/jcm.3.1.21-25.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Rudbach J. A., Reed N. D. Immunological responses of mice to lipopolysaccharide: lack of secondary responsiveness by C3H/HeJ mice. Infect Immun. 1977 May;16(2):513–517. doi: 10.1128/iai.16.2.513-517.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Schott C. F., Merchant B. Carrier-specific immune memory to a thymus-independent antigen in congenitally athymic mice. J Immunol. 1979 May;122(5):1710–1718. [PubMed] [Google Scholar]
  24. Schrader J. W. The role of T cells in IgG production; thymus-dependent antigens induce B cell memory in the absence of T cells. J Immunol. 1975 Jun;114(6):1665–1669. [PubMed] [Google Scholar]
  25. Syeklocha D., Siminovitch L., Till J. E., McCulloch E. A. The proliferative state of antigen-sensitive precursors of hemolysin-producing cells, determined by the use of the inhibitor, vinblastine. J Immunol. 1966 Mar;96(3):472–477. [PubMed] [Google Scholar]
  26. Von Eschen K. B., Rudbach J. A. Immunological responses of mice to native protoplasmic polysaccharide and lipopolysaccharide: functional separation of the two signals required to stimulate a secondary antibody response. J Exp Med. 1974 Dec 1;140(6):1604–1614. doi: 10.1084/jem.140.6.1604. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES