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. 1985 Jul;49(1):141–144. doi: 10.1128/iai.49.1.141-144.1985

Arachidonic acid facilitates experimental chronic osteomyelitis in rats.

J P Rissing, T B Buxton, J Fisher, R Harris, R K Shockley
PMCID: PMC262070  PMID: 3924826

Abstract

Arachidonic acid was used as a facilitating agent in experimental rat Staphylococcus aureus osteomyelitis and compared with the more commonly used agent, sodium morrhuate. The injection of arachidonic acid or sodium morrhuate and S. aureus into rat tibiae caused increased quantitative bacterial bone counts, gross bone pathology, roentgenographic changes, and weight loss. The doses required to produce these changes appeared to be lower for arachidonic acid.

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Selected References

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