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. 1986 Apr;52(1):12–17. doi: 10.1128/iai.52.1.12-17.1986

Effect of cyclosporin A on immunity to Listeria monocytogenes.

A W Hügin, A Cerny, M Wrann, H Hengartner, R M Zinkernagel
PMCID: PMC262190  PMID: 3485573

Abstract

The effect of the immunosuppressive drug cyclosporin A (CS-A) on immunity to the facultative intracellular bacterium Listeria monocytogenes was investigated in unprimed and primed mice. Different treatment protocols were followed to evaluate the time dependence of CS-A-mediated immune suppression and the effect of CS-A on immunological memory to L. monocytogenes. The effect of CS-A was observed only during and after activation of T cell-mediated immunity, whereas early resistance exerted by macrophages assessed 6 and 70 min after challenge remained unaffected. CS-A suppressed efficient elimination of L. monocytogenes even when given after day 3 of a primary infection. This contrasts with findings in other models, including viral infections, where CS-A must be administered very early in an immune response to suppress it. CS-A suppressed antibacterial resistance in mice primed at various times before challenge; suppression of protection was time dependent and was virtually complete in livers, whereas CS-A-resistant memory persisted in spleens for up to 10 months.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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