TABLE 4.
Summary of multiple multivariate logistic regressions for nephropathy
| Covariate effects from multiple models |
df | χ2 | P value | R2 |
|---|---|---|---|---|
| Unadjusted effect | ||||
| DCCT mean A1C | 1 | 10.4 | 0.0012 | 0.062 |
| EDIC study mean A1C | 1 | 32.0 | <0.0001 | 0.189 |
| Log DCCT close-out AER | 1 | 13.6 | 0.0002 | 0.081 |
| Furosine, CML, pentosidine, fluorescence, acid/pepsin soluble |
6 | 19.3 | 0.0036 | 0.114 |
| Pentosidine, fluorescence, acid/pepsin soluble |
4 | 12.6 | 0.0135 | 0.075 |
| Furosine, CML | 2 | 18.2 | 0.0001 | 0.108 |
| Furosine | 1 | 13.4 | 0.0002 | 0.080 |
| CML | 1 | 10.2 | 0.0014 | 0.060 |
| Adjusted effect | ||||
| DCCT mean A1C effect adjusted for |
||||
| Furosine, CML | 1 | 0.0 | 0.9643 | 0.000 |
| Furosine | 1 | 0.2 | 0.6413 | 0.001 |
| CML | 1 | 4.8 | 0.0278 | 0.029 |
| DCCT mean A1C, log AER effect adjusted for |
||||
| Furosine, CML | 2 | 10.8 | 0.0046 | 0.064 |
| EDIC study mean A1C effect adjusted for |
||||
| Furosine, CML | 1 | 23.1 | <0.0001 | 0.137 |
| Furosine | 1 | 21.8 | <0.0001 | 0.129 |
| CML | 1 | 26.0 | <0.0001 | 0.154 |
| Furosine, CML effect adjusted for |
||||
| Pentosidine, fluorescence, acid/pepsin soluble |
2 | 11.0 | 0.0041 | 0.065 |
| DCCT mean A1C, log | ||||
| AER | 2 | 13.1 | 0.0014 | 0.078 |
| DCCT mean A1C | 2 | 12.8 | 0.0016 | 0.076 |
| EDIC study mean A1C | 2 | 14.4 | 0.0008 | 0.085 |
| Pentosidine, fluorescence, acid/pepsin soluble effect adjusted for |
||||
| Furosine, CML | 4 | 4.5 | 0.3394 | 0.027 |
| Furosine effect adjusted for | ||||
| DCCT mean A1C | 1 | 7.1 | 0.0079 | 0.042 |
| EDIC study mean A1C | 1 | 7.1 | 0.0076 | 0.042 |
| CML effect adjusted for | ||||
| DCCT mean A1C | 1 | 6.3 | 0.0123 | 0.037 |
| EDIC study mean A1C | 1 | 10.7 | 0.0011 | 0.064 |
Dependent variable: development of microalbuminuria or worse from DCCT close out through EDIC study year 10. As defined in the statistical methods section, χ2 and P values are from likelihood ratio test, and R2 is entropy R2.