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. 1986 Feb;51(2):642–647. doi: 10.1128/iai.51.2.642-647.1986

Adherence of oral treponemes and their effect on morphological damage and detachment of epithelial cells in vitro.

F M Reijntjens, F H Mikx, J M Wolters-Lutgerhorst, J C Maltha
PMCID: PMC262395  PMID: 3943904

Abstract

The present study shows adherence of Treponema denticola L12D and Treponema vincentii RitzA to guinea pig ear epithelial cells in vitro. The number of adhering organisms was positively related with the treponemal concentration and contact time. Incubation of washed T. denticola L12D and T. vincentii RitzA organisms or their culture supernatants with the epithelial cells induced morphological damage and detachment of these cells. In addition, indications for inhibition of epithelial cell proliferation were found. The activity of the supernatants was dose dependent, heat sensitive, and sensitive to sulfhydryl-containing components, suggesting the presence of enzymatic activity that might be of importance in the pathogenicity of these oral treponemes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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