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. 1986 Feb;51(2):687–689. doi: 10.1128/iai.51.2.687-689.1986

In vivo identification of sialic acid as the ocular receptor for Pseudomonas aeruginosa.

L D Hazlett, M Moon, R S Berk
PMCID: PMC262407  PMID: 3080374

Abstract

In vivo bacterial adherence of Pseudomonas aeruginosa to the immature ocular epithelium was mediated by a sialic (N-acetylneuraminic) acid (NANA) receptor. Saturation of binding sites on the bacterial surface by NANA prevented attachment of the organism to the epithelial cell membrane receptor. Additionally, a significant number of animals receiving NANA-treated organisms were protected from septicemia and death. In vivo protection studies showed excellent correlation with scanning electron microscopy, in that the number of adherent organisms at the corneal surface decreased dramatically in the presence of NANA. These studies exhibit a strong correlation with clinical cases of human infant ocular infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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