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letter
. 1987 Aug;79(8):809–814.

Electrocardiogram Analysis in Adult Patients With Sickle Cell Disease

Kirk L Holloman, Cage S Johnson, L Julian Haywood
PMCID: PMC2625565  PMID: 3508215

Abstract

This study is an analysis of the electrocardiograms (ECGs) of 87 adult patients taken during hospital admission for sickle cell disease (homozygous S). The age range was 18 to 55 years: 38 were men and 49 were women. Seventy-two percent of all patients had abnormal ECGs. Nonspecific ST-T (NS-ST-T) wave abnormalities (53 percent) and QT interval prolongation (12 percent) were frequent. Seventy-five percent of the normal ECGs occurred in women (P < .05); and 74 percent of those with left ventricular hypertrophy (LVH) were men (P < .05). Fifteen of 21 (71 percent) patients with arrhythmias had NS-ST-T abnormalities. Systemic hypertension and ECG evidence for right-sided heart disease were rare, as was the incidence of LVH by ECG.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BISHOP J. M., DONALD K. W., WADE O. L. Circulatory dynamics at rest and on exercise in the hyperkinetic states. Clin Sci. 1955 May;14(2):329–360. [PubMed] [Google Scholar]
  2. Brannon E. S., Merrill A. J., Warren J. V., Stead E. A. THE CARDIAC OUTPUT IN PATIENTS WITH CHRONIC ANEMIA AS MEASURED BY THE TECHNIQUE OF RIGHT ATRIAL CATHETERIZATION. J Clin Invest. 1945 May;24(3):332–336. doi: 10.1172/JCI101610. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Duke M., Abelmann W. H. The hemodynamic response to chronic anemia. Circulation. 1969 Apr;39(4):503–515. doi: 10.1161/01.cir.39.4.503. [DOI] [PubMed] [Google Scholar]
  4. Fowler N. O., Holmes J. C. Ventricular function in anemia. J Appl Physiol. 1971 Aug;31(2):260–265. doi: 10.1152/jappl.1971.31.2.260. [DOI] [PubMed] [Google Scholar]
  5. GOLDBERGER E. A simple method of determining abnormalities of the Q-T interval. Am Heart J. 1948 Jul;36(1):141–143. doi: 10.1016/0002-8703(48)90554-7. [DOI] [PubMed] [Google Scholar]
  6. GRAETTINGER J. S., PARSONS R. L., CAMPBELL J. A. A correlation of clinical and hemodynamic studies in patients with mild and severe anemia with and without congestive failure. Ann Intern Med. 1963 Apr;58:617–626. doi: 10.7326/0003-4819-58-4-617. [DOI] [PubMed] [Google Scholar]
  7. GRUBSCHMIDT H. A., SOKOLOW M. The reliability of high voltage of the QRS complex as a diagnostic sign of left ventricular hypertrophy in adults. Am Heart J. 1957 Nov;54(5):689–694. doi: 10.1016/0002-8703(57)90423-4. [DOI] [PubMed] [Google Scholar]
  8. Gerry J. L., Baird M. G., Fortuin N. J. Evaluation of left ventricular function in patients with sickle cell anemia. Am J Med. 1976 Jun;60(7):968–972. doi: 10.1016/0002-9343(76)90568-4. [DOI] [PubMed] [Google Scholar]
  9. HENDERSON A. B. Sickle cell anemia; clinical study of fifty-four cases. Am J Med. 1950 Dec;9(6):757–765. doi: 10.1016/0002-9343(50)90291-9. [DOI] [PubMed] [Google Scholar]
  10. JONES H. L., Jr, WETZEL F. E., BLACK B. K. Sickle cell anemia with striking electrocardiographic abnormalities and other unusual features, with autopsy. Ann Intern Med. 1948 Nov;29(5):928–935. doi: 10.7326/0003-4819-29-5-928. [DOI] [PubMed] [Google Scholar]
  11. LEIGHT L., SNIDER T. H., CLIFFORD G. O., HELLEMS H. K. Hemodynamic studies in sickle cell anemia. Circulation. 1954 Nov;10(5):653–662. doi: 10.1161/01.cir.10.5.653. [DOI] [PubMed] [Google Scholar]
  12. LEPESCHKIN E., SURAWICZ B. The measurement of the Q-T interval of the electrocardiogram. Circulation. 1952 Sep;6(3):378–388. doi: 10.1161/01.cir.6.3.378. [DOI] [PubMed] [Google Scholar]
  13. LINDO C. L., DOCTOR L. R. The electrocardiogram in sickle-cell anemia. Am Heart J. 1955 Aug;50(2):218–224. doi: 10.1016/0002-8703(55)90318-5. [DOI] [PubMed] [Google Scholar]
  14. Lindsay J., Jr, Meshel J. C., Patterson R. H. The cardiovascular manifestations of sickle cell disease. Arch Intern Med. 1974 Apr;133(4):643–651. [PubMed] [Google Scholar]
  15. MANNING G. W., SMILEY J. R. QRS-VOLTAGE CRITERIA FOR LEFT VENTRICULAR HYPERTROPHY IN A NORMAL MALE POPULATION. Circulation. 1964 Feb;29:224–230. doi: 10.1161/01.cir.29.2.224. [DOI] [PubMed] [Google Scholar]
  16. MARGOLIES M. P. Sickle cell anemia; a composite study and survey. Medicine (Baltimore) 1951 Dec;30(4):357–433. doi: 10.1097/00005792-195112000-00003. [DOI] [PubMed] [Google Scholar]
  17. MASSUMI R. A., PIPBERGER H., PRINZMETAL M., SCHWARTZ L. Studies on the nature of the repolarization process. XIX. Studies on the mechanism of ventricular activity. Am Heart J. 1957 Jan;53(1):100–124. doi: 10.1016/0002-8703(57)90387-3. [DOI] [PubMed] [Google Scholar]
  18. MILNOR W. R. Electrocardiogram and vectorcardiogram in right ventricular hypertrophy and right bundle-branch block. Circulation. 1957 Sep;16(3):348–367. doi: 10.1161/01.cir.16.3.348. [DOI] [PubMed] [Google Scholar]
  19. MORRIS J. J., Jr, ESTES E. H., Jr, WHALEN R. E., THOMPSON H. K., Jr, MCINTOSH H. D. P-WAVE ANALYSIS IN VALVULAR HEART DISEASE. Circulation. 1964 Feb;29:242–252. doi: 10.1161/01.cir.29.2.242. [DOI] [PubMed] [Google Scholar]
  20. MULET M., KAUFMAN J. M. The electrocardiogram in 50 cases of sickle-cell anaemia. East Afr Med J. 1962 May;39:232–234. [PubMed] [Google Scholar]
  21. Ng M. L., Liebman J., Anslovar J., Gross S. Cardiovascular findings in children with sickle cell anemia. Dis Chest. 1967 Dec;52(6):788–799. doi: 10.1378/chest.52.6.788. [DOI] [PubMed] [Google Scholar]
  22. ROY S. B., BHATIA M. L., MATHUR V. S., VIRMANI S. HEMODYNAMIC EFFECTS OF CHRONIC SEVERE ANEMIA. Circulation. 1963 Sep;28:346–356. doi: 10.1161/01.cir.28.3.346. [DOI] [PubMed] [Google Scholar]
  23. Rosenbaum M. B. The hemiblocks: diagnostic criteria and clinical significance. Mod Concepts Cardiovasc Dis. 1970 Dec;39(12):141–146. [PubMed] [Google Scholar]
  24. SPROULE B. J., HALDEN E. R., MILLER W. F. A study of cardiopulmonary alterations in patients with sickle cell disease and its variants. J Clin Invest. 1958 Mar;37(3):486–495. doi: 10.1172/JCI103629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Savage D. D., Seides S. F., Clark C. E., Henry W. L., Maron B. J., Robinson F. C., Epstein S. E. Electrocardiographic findings in patients with obstructive and nonobstructive hypertrophic cardiomyopathy. Circulation. 1978 Sep;58(3 Pt 1):402–408. doi: 10.1161/01.cir.58.3.402. [DOI] [PubMed] [Google Scholar]
  26. UZSOY N. K. CARDIOVASCULAR FINDINGS IN PATIENTS WITH SICKLE CELL ANEMIA. Am J Cardiol. 1964 Mar;13:320–328. doi: 10.1016/0002-9149(64)90447-3. [DOI] [PubMed] [Google Scholar]
  27. VAN DAMR, DURRER D. THE T WAVE AND VENTRICULAR REPOLARIZATION. Am J Cardiol. 1964 Sep;14:294–300. doi: 10.1016/0002-9149(64)90071-2. [DOI] [PubMed] [Google Scholar]
  28. Varat M. A., Adolph R. J., Fowler N. O. Cardiovascular effects of anemia. Am Heart J. 1972 Mar;83(3):415–426. doi: 10.1016/0002-8703(72)90445-0. [DOI] [PubMed] [Google Scholar]
  29. Vincent G. M., Abildskov J. A., Burgess M. J. Q-T interval syndromes. Prog Cardiovasc Dis. 1974 May-Jun;16(6):523–530. doi: 10.1016/0033-0620(74)90016-4. [DOI] [PubMed] [Google Scholar]

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