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letter
. 1988 Aug;80(8):906–912.

Intravascular Volume Expansion and Fetal Outcome in Pregnant Nigerians With Hemoglobin SS and SC

Olalekan O Abudu, Olusoga A Sofola
PMCID: PMC2625713  PMID: 3246704

Abstract

In a comparative study of physiological changes in pregnant Nigerians, plasma volume measurements were performed in 75 healthy Nigerian women. They comprised 40 women with hemoglobin genotype AA (20 pregnant and 20 nonpregnant) and 35 women with hemoglobin genotype SS or SC (15 pregnant and 20 nonpregnant). Plasma volume was determined in the left lateral position using the Evans blue dye dilution technique (described by Dacie and Lewis) in the nonpregnant, at 16 and 36 weeks of gestation, and at 8 weeks postpartum.

The mean plasma volume of 2044 ± 77.4 mL (SEM) in normal nonpregnant women with Hb AA was not significantly different from the mean plasma volume of 1931 ± 115 mL (SEM) found in nonpregnant sicklers. At 16 weeks' gestation there was no significant difference in the mean plasma volume of 2712 ± 209.8 mL (SEM) in pregnant women with HB AA and 2948 ± 165.8 mL (SEM) in pregnant sicklers. However, at 36 weeks the mean plasma volume of 3440 ± 223.7 mL (SEM) (68 percent increase compared with nonpregnant) in pregnant women with Hb AA was significantly higher (P < .02) than the mean plasma volume of 2312 ± 214.8 mL (SEM) (17 percent increase compared with nonpregnant) in sicklers.

The mean birthweight of 3.17 ± 0.08 kg (SEM) in women with Hb AA was higher (P < .01) than that of 2.58 ± 0.15 kg (SEM) in sicklers. The perinatal mortality in sicklers was 133/thousand total births, while there was no fetal loss in the control. These data suggest a decrease or lack of intravascular volume expansion and evidence of uteroplacental insufficiency in sicklers.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ANDERSON M., WENT L. N., MACIVER J. E., DIXON H. G. Sicklecell disease in pregnancy. Lancet. 1960 Sep 3;2(7149):516–521. doi: 10.1016/s0140-6736(60)91544-0. [DOI] [PubMed] [Google Scholar]
  2. Abudu O. O., Sofola O. A. Plasma volume in normal pregnant Nigerian primigravidae. Int J Gynaecol Obstet. 1985 Apr;23(2):137–142. doi: 10.1016/0020-7292(85)90059-1. [DOI] [PubMed] [Google Scholar]
  3. Addae S., Konotey-Ahulu F. I. Lack of diurnal variations in sodium, potassium and osmolal excretion in the sickle cell patient. Afr J Med Sci. 1971 Oct;2(4):349–359. [PubMed] [Google Scholar]
  4. Agboola A. Effect of type and duration of anemia on placental weight and villous histology. J Natl Med Assoc. 1979 Nov;71(11):1067–1069. [PMC free article] [PubMed] [Google Scholar]
  5. Brosens I., Dixon H. G., Robertson W. B. Fetal growth retardation and the arteries of the placental bed. Br J Obstet Gynaecol. 1977 Sep;84(9):656–663. doi: 10.1111/j.1471-0528.1977.tb12676.x. [DOI] [PubMed] [Google Scholar]
  6. Cunningham F. G., Pritchard J. A., Mason R., Chase G. Prophylactic transfusions of normal red blood cells during pregnancies complicated by sickle cell hemoglobinopathies. Am J Obstet Gynecol. 1979 Dec 1;135(7):994–1003. doi: 10.1016/0002-9378(79)90825-1. [DOI] [PubMed] [Google Scholar]
  7. HATCH F. E., DIGGS L. W. FLUID BALANCE IN SICKLE-CELL DISEASE. Arch Intern Med. 1965 Jul;116:10–17. doi: 10.1001/archinte.1965.03870010012003. [DOI] [PubMed] [Google Scholar]
  8. HYTTEN F. E., PAINTIN D. B. Increase in plasma volume during normal pregnancy. J Obstet Gynaecol Br Emp. 1963 Jun;70:402–407. doi: 10.1111/j.1471-0528.1963.tb04922.x. [DOI] [PubMed] [Google Scholar]
  9. Harrison K. A., Ibeziako P. A. Maternal anaemia and fetal birthweight. J Obstet Gynaecol Br Commonw. 1973 Sep;80(9):798–804. doi: 10.1111/j.1471-0528.1973.tb11221.x. [DOI] [PubMed] [Google Scholar]
  10. Hendrickse J. P., Watson-Williams E. J., Luzzatto L., Ajabor L. N. Pregnancy in homozygous sickle-cell anaemia. J Obstet Gynaecol Br Commonw. 1972 May;79(5):396–409. doi: 10.1111/j.1471-0528.1972.tb14177.x. [DOI] [PubMed] [Google Scholar]
  11. Howie P. W. Causes of intrauterine growth retardation. Br Med J (Clin Res Ed) 1982 Jul 17;285(6336):156–157. doi: 10.1136/bmj.285.6336.156. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Marwah P., Singla P. N., Krishna M., Agarwal K. N. Effect of pregnancy anaemia on cellular growth in the human placenta. Acta Paediatr Scand. 1979 Nov;68(6):899–901. doi: 10.1111/j.1651-2227.1979.tb08230.x. [DOI] [PubMed] [Google Scholar]
  13. Pirani B. B., Campbell D. M., MacGillivray I. Plasma volume in normal first pregnancy. J Obstet Gynaecol Br Commonw. 1973 Oct;80(10):884–887. doi: 10.1111/j.1471-0528.1973.tb02146.x. [DOI] [PubMed] [Google Scholar]
  14. Thomson A. M., Billewicz W. Z., Hytten F. E. The assessment of fetal growth. J Obstet Gynaecol Br Commonw. 1968 Sep;75(9):903–916. doi: 10.1111/j.1471-0528.1968.tb01615.x. [DOI] [PubMed] [Google Scholar]
  15. Tuck S. M. Sickle-cell disease and pregnancy. Br J Hosp Med. 1982 Aug;28(2):125–127. [PubMed] [Google Scholar]
  16. Tuck S. M., Studd J. W., White J. M. Pregnancy in sickle cell disease in the UK. Br J Obstet Gynaecol. 1983 Feb;90(2):112–117. doi: 10.1111/j.1471-0528.1983.tb08893.x. [DOI] [PubMed] [Google Scholar]

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