Abstract
A 59-year-old woman was admitted to the hospital with ovarian carcinoma. After cytoreductive surgery, the patient developed intra-abdominal sepsis. After 17 days of intravenous imipenem, the patient's sputum culture grew imipenem-resistant Pseudomonas aeruginosa. On the 21st day of treatment with imipenem, her peritoneal culture also grew imipenem-resistant Pseudomonas aeruginosa.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Acar J. F. Therapy for lower respiratory tract infections with imipenem/cilastatin: a review of worldwide experience. Rev Infect Dis. 1985 Jul-Aug;7 (Suppl 3):S513–S517. doi: 10.1093/clinids/7.supplement_3.s513. [DOI] [PubMed] [Google Scholar]
- Angus B. L., Carey A. M., Caron D. A., Kropinski A. M., Hancock R. E. Outer membrane permeability in Pseudomonas aeruginosa: comparison of a wild-type with an antibiotic-supersusceptible mutant. Antimicrob Agents Chemother. 1982 Feb;21(2):299–309. doi: 10.1128/aac.21.2.299. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Aronoff S. C., Shlaes D. M. Factors that influence the evolution of beta-lactam resistance in beta-lactamase-inducible strains of Enterobacter cloacae and Pseudomonas aeruginosa. J Infect Dis. 1987 May;155(5):936–941. doi: 10.1093/infdis/155.5.936. [DOI] [PubMed] [Google Scholar]
- Bell S. M., Pham J. N., Lanzarone J. Y. Mutation of Pseudomonas aeruginosa to piperacillin resistance mediated by beta-lactamase production. J Antimicrob Chemother. 1985 Jun;15(6):665–670. doi: 10.1093/jac/15.6.665. [DOI] [PubMed] [Google Scholar]
- Bryan L. E., Kwan S., Godfrey A. J. Resistance of Pseudomonas aeruginosa mutants with altered control of chromosomal beta-lactamase to piperacillin, ceftazidime, and cefsulodin. Antimicrob Agents Chemother. 1984 Mar;25(3):382–384. doi: 10.1128/aac.25.3.382. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Büscher K. H., Cullmann W., Dick W., Opferkuch W. Imipenem resistance in Pseudomonas aeruginosa resulting from diminished expression of an outer membrane protein. Antimicrob Agents Chemother. 1987 May;31(5):703–708. doi: 10.1128/aac.31.5.703. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Büscher K. H., Cullmann W., Dick W., Wendt S., Opferkuch W. Imipenem resistance in Pseudomonas aeruginosa is due to diminished expression of outer membrane proteins. J Infect Dis. 1987 Oct;156(4):681–684. doi: 10.1093/infdis/156.4.681. [DOI] [PubMed] [Google Scholar]
- Fan W., del Busto R., Love M., Markowitz N., Cendrowski C., Cardenas J., Quinn E., Saravolatz L. Imipenem-cilastatin in the treatment of methicillin-sensitive and methicillin-resistant Staphylococcus aureus infections. Antimicrob Agents Chemother. 1986 Jan;29(1):26–29. doi: 10.1128/aac.29.1.26. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Freimer E. H., Donabedian H., Raeder R., Ribner B. S. Empirical use of imipenem as the sole antibiotic in the treatment of serious infections. J Antimicrob Chemother. 1985 Oct;16(4):499–507. doi: 10.1093/jac/16.4.499. [DOI] [PubMed] [Google Scholar]
- Imipenem/cilastatin versus gentamicin/clindamycin for treatment of serious bacterial infections. Report from a Scandinavian Study Group. Lancet. 1984 Apr 21;1(8382):868–871. [PubMed] [Google Scholar]
- Knothe H., Antal M., Krcméry V. Imipenem and ceftazidime resistance in Pseudomonas aeruginosa and Klebsiella pneumoniae. J Antimicrob Chemother. 1987 Jan;19(1):136–138. doi: 10.1093/jac/19.1.136. [DOI] [PubMed] [Google Scholar]
- Pedersen S. S., Pressler T., Høiby N., Bentzon M. W., Koch C. Imipenem/cilastatin treatment of multiresistant Pseudomonas aeruginosa lung infection in cystic fibrosis. J Antimicrob Chemother. 1985 Nov;16(5):629–635. doi: 10.1093/jac/16.5.629. [DOI] [PubMed] [Google Scholar]
- Quinn J. P., Dudek E. J., DiVincenzo C. A., Lucks D. A., Lerner S. A. Emergence of resistance to imipenem during therapy for Pseudomonas aeruginosa infections. J Infect Dis. 1986 Aug;154(2):289–294. doi: 10.1093/infdis/154.2.289. [DOI] [PubMed] [Google Scholar]
- Saino Y., Kobayashi F., Inoue M., Mitsuhashi S. Purification and properties of inducible penicillin beta-lactamase isolated from Pseudomonas maltophilia. Antimicrob Agents Chemother. 1982 Oct;22(4):564–570. doi: 10.1128/aac.22.4.564. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Vurma-Rapp U., Kayser F. H., Barberis-Maino L. Antibacterial properties of imipenem with special reference to the activity against methicillin-resistant staphylococci, cefotaxime-resistant Enterobacteriaceae and Pseudomonas aeruginosa. J Antimicrob Chemother. 1986 Dec;18 (Suppl E):27–33. doi: 10.1093/jac/18.supplement_e.27. [DOI] [PubMed] [Google Scholar]
- Winston D. J., McGrattan M. A., Busuttil R. W. Imipenem therapy of Pseudomonas aeruginosa and other serious bacterial infections. Antimicrob Agents Chemother. 1984 Nov;26(5):673–677. doi: 10.1128/aac.26.5.673. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Witte J. L., Sapico F. L., Canawati H. N. In vitro susceptibility of methicillin-resistant and methicillin-susceptible Staphylococcus aureus strains to N-formimidoyl thienamycin. Antimicrob Agents Chemother. 1982 Nov;22(5):906–908. doi: 10.1128/aac.22.5.906. [DOI] [PMC free article] [PubMed] [Google Scholar]
