Abstract
The presenting signs and symptoms of isoniazid toxicity are discussed, with a review of the complications and management of this metabolic encephalopathy with B6 pyridoxine. This study supports previous studies in finding that ingestion of more than 80 mg/kg body weight produces severe central nervous system symptoms that are rapidly reversed with intravenous administration of pyridoxine.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chin L., Picchioni A. L., Bourn W. M., Laird H. E. Optimal antidotal dose of activated charcoal. Toxicol Appl Pharmacol. 1973 Sep;26(1):103–108. doi: 10.1016/0041-008x(73)90090-2. [DOI] [PubMed] [Google Scholar]
- HUGHES H. B., BIEHL J. P., JONES A. P., SCHMIDT L. H. Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis. Am Rev Tuberc. 1954 Aug;70(2):266–273. doi: 10.1164/art.1954.70.2.266. [DOI] [PubMed] [Google Scholar]
- Hankins D. G., Saxena K., Faville R. J., Jr, Warren B. J. Profound acidosis caused by isoniazid ingestion. Am J Emerg Med. 1987 Mar;5(2):165–166. doi: 10.1016/0735-6757(87)90098-2. [DOI] [PubMed] [Google Scholar]
- O'Brien T. F., Hopkins J. D., Gilleece E. S., Medeiros A. A., Kent R. L., Blackburn B. O., Holmes M. B., Reardon J. P., Vergeront J. M., Schell W. L. Molecular epidemiology of antibiotic resistance in salmonella from animals and human beings in the United States. N Engl J Med. 1982 Jul 1;307(1):1–6. doi: 10.1056/NEJM198207013070101. [DOI] [PubMed] [Google Scholar]
- Sievers M. L., Herrier R. N. Treatment of acute isoniazid toxicity. Am J Hosp Pharm. 1975 Feb;32(2):202–206. [PubMed] [Google Scholar]
- Takayama K., Schnoes H. K., Armstrong E. L., Boyle R. W. Site of inhibitory action of isoniazid in the synthesis of mycolic acids in Mycobacterium tuberculosis. J Lipid Res. 1975 Jul;16(4):308–317. [PubMed] [Google Scholar]
- Wason S., Lacouture P. G., Lovejoy F. H., Jr Single high-dose pyridoxine treatment for isoniazid overdose. JAMA. 1981 Sep 4;246(10):1102–1104. [PubMed] [Google Scholar]