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Journal of the National Medical Association logoLink to Journal of the National Medical Association
. 1991 Jan;83(1):75–77.

Propylthiouracil-associated hepatitis.

S A Peter 1
PMCID: PMC2627005  PMID: 1994070

Abstract

The case of a 43-year-old female with propylthiouracil-induced hepatitis is reported. The case is unique because the patient's liver function deteriorated 2 weeks after medication was discontinued.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fedotin M. S., Lefer L. G. Liver disease caused by propylthiouracil. Arch Intern Med. 1975 Feb;135(2):319–321. [PubMed] [Google Scholar]
  2. Garty B. Z., Kauli R., Ben-Ari J., Lubin E., Nitzan M., Laron Z. Hepatitis associated with propylthiouracil treatment. Drug Intell Clin Pharm. 1985 Oct;19(10):740–742. doi: 10.1177/106002808501901009. [DOI] [PubMed] [Google Scholar]
  3. Hopf U., Meyer zum Büschenfelde K. H., Arnold W. Detection of a liver-membrane autoantibody in HBsAg-negative chronic active hepatitis. N Engl J Med. 1976 Mar 11;294(11):578–582. doi: 10.1056/NEJM197603112941103. [DOI] [PubMed] [Google Scholar]
  4. Jonas M. M., Eidson M. S. Propylthiouracil hepatotoxicity: two pediatric cases and review of the literature. J Pediatr Gastroenterol Nutr. 1988 Sep-Oct;7(5):776–779. [PubMed] [Google Scholar]
  5. Limaye A., Ruffolo P. R. Propylthiouracil-induced fatal hepatic necrosis. Am J Gastroenterol. 1987 Feb;82(2):152–154. [PubMed] [Google Scholar]
  6. Mihas A. A., Holley P., Koff R. S., Hirschowitz B. I. Fulminant hepatitis and lymphocyte sensitization due to propylthiouracil. Gastroenterology. 1976 May;70(5 PT1):770–774. [PubMed] [Google Scholar]
  7. Okita N., Row V. V., Volpe R. Suppressor T-lymphocyte deficiency in Graves' disease and Hashimoto's thyroiditis. J Clin Endocrinol Metab. 1981 Mar;52(3):528–533. doi: 10.1210/jcem-52-3-528. [DOI] [PubMed] [Google Scholar]
  8. Reddy C. M. Propylthiouracil and hepatitis: a case report. J Natl Med Assoc. 1979 Dec;71(12):1185–1186. [PMC free article] [PubMed] [Google Scholar]
  9. Safani M. M., Tatro D. S., Rudd P. Fatal propylthiouracil-induced hepatitis. Arch Intern Med. 1982 Apr;142(4):838–839. [PubMed] [Google Scholar]
  10. Vergani G. M., Vergani D., Jenkins P. J., Portmann B., Mowat A. P., Eddleston A. L., Williams R. Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg-negative chronic active hepatitis. Clin Exp Immunol. 1979 Oct;38(1):16–21. [PMC free article] [PubMed] [Google Scholar]
  11. Weiss M., Hassin D., Bank H. Propylthiouracil-induced hepatic damage. Arch Intern Med. 1980 Sep;140(9):1184–1185. [PubMed] [Google Scholar]

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