Skip to main content
Emerging Infectious Diseases logoLink to Emerging Infectious Diseases
. 1997 Jan-Mar;3(1):59–62. doi: 10.3201/eid0301.970107

Isolation and phylogenetic characterization of Ebola viruses causing different outbreaks in Gabon.

M C Georges-Courbot 1, A Sanchez 1, C Y Lu 1, S Baize 1, E Leroy 1, J Lansout-Soukate 1, C Tévi-Bénissan 1, A J Georges 1, S G Trappier 1, S R Zaki 1, R Swanepoel 1, P A Leman 1, P E Rollin 1, C J Peters 1, S T Nichol 1, T G Ksiazek 1
PMCID: PMC2627600  PMID: 9126445

Abstract

Three outbreaks of Ebola hemorrhagic fever have recently occurred in Gabon. Virus has been isolated from clinical materials from all three outbreaks, and nucleotide sequence analysis of the glycoprotein gene of the isolates and virus present in clinical samples has been carried out. These data indicate that each of the three outbreaks should be considered an independent emergence of a different Ebola virus of the Zaire subtype. As in earlier Ebola virus outbreaks, no genetic variability was detected between virus samples taken during an individual outbreak.

Full Text

The Full Text of this article is available as a PDF (259.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cox N. J., McCormick J. B., Johnson K. M., Kiley M. P. Evidence for two subtypes of Ebola virus based on oligonucleotide mapping of RNA. J Infect Dis. 1983 Feb;147(2):272–275. doi: 10.1093/infdis/147.2.272. [DOI] [PubMed] [Google Scholar]
  2. Fisher-Hoch S. P., Brammer T. L., Trappier S. G., Hutwagner L. C., Farrar B. B., Ruo S. L., Brown B. G., Hermann L. M., Perez-Oronoz G. I., Goldsmith C. S. Pathogenic potential of filoviruses: role of geographic origin of primate host and virus strain. J Infect Dis. 1992 Oct;166(4):753–763. doi: 10.1093/infdis/166.4.753. [DOI] [PubMed] [Google Scholar]
  3. Ivanoff B., Duquesnoy P., Languillat G., Saluzzo J. F., Georges A., Gonzalez J. P., McCormick J. Haemorrhagic fever in Gabon. I. Incidence of Lassa, Ebola and Marburg viruses in Haut-Ogooué. Trans R Soc Trop Med Hyg. 1982;76(6):719–720. doi: 10.1016/0035-9203(82)90089-x. [DOI] [PubMed] [Google Scholar]
  4. Jahrling P. B., Geisbert T. W., Jaax N. K., Hanes M. A., Ksiazek T. G., Peters C. J. Experimental infection of cynomolgus macaques with Ebola-Reston filoviruses from the 1989-1990 U.S. epizootic. Arch Virol Suppl. 1996;11:115–134. doi: 10.1007/978-3-7091-7482-1_11. [DOI] [PubMed] [Google Scholar]
  5. Le Guenno B., Formenty P., Formentry P., Wyers M., Gounon P., Walker F., Boesch C. Isolation and partial characterisation of a new strain of Ebola virus. Lancet. 1995 May 20;345(8960):1271–1274. doi: 10.1016/s0140-6736(95)90925-7. [DOI] [PubMed] [Google Scholar]
  6. Sanchez A., Trappier S. G., Mahy B. W., Peters C. J., Nichol S. T. The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing. Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3602–3607. doi: 10.1073/pnas.93.8.3602. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Emerging Infectious Diseases are provided here courtesy of Centers for Disease Control and Prevention

RESOURCES