Abstract
In part, Cyclospora cayetanensis owes its recognition as an emerging pathogen to the increased use of staining methods for detecting enteric parasites such as Cryptosporidium. First reported in patients in New Guinea in 1977 but thought to be a coccidian parasite of the genus Isospora, C. cayetanensis received little attention until it was again described in 1985 in New York and Peru. In the early 1990s, human infection associated with waterborne transmission of C. cayetanensis was suspected; foodborne transmission was likewise suggested in early studies. The parasite was associated with several disease outbreaks in the United States during 1996 and 1997. This article reviews current knowledge about C. cayetanensis (including its association with waterborne and foodborne transmission), unresolved issues, and research needs.
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Selected References
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- Ashford R. W. Occurrence of an undescribed coccidian in man in Papua New Guinea. Ann Trop Med Parasitol. 1979 Oct;73(5):497–500. doi: 10.1080/00034983.1979.11687291. [DOI] [PubMed] [Google Scholar]
- Bendall R. P., Lucas S., Moody A., Tovey G., Chiodini P. L. Diarrhoea associated with cyanobacterium-like bodies: a new coccidian enteritis of man. Lancet. 1993 Mar 6;341(8845):590–592. doi: 10.1016/0140-6736(93)90352-h. [DOI] [PubMed] [Google Scholar]
- Connor B. A., Shlim D. R. Foodborne transmission of Cyclospora. Lancet. 1995 Dec 16;346(8990):1634–1634. doi: 10.1016/s0140-6736(95)91972-4. [DOI] [PubMed] [Google Scholar]
- DuPont H. L., Chappell C. L., Sterling C. R., Okhuysen P. C., Rose J. B., Jakubowski W. The infectivity of Cryptosporidium parvum in healthy volunteers. N Engl J Med. 1995 Mar 30;332(13):855–859. doi: 10.1056/NEJM199503303321304. [DOI] [PubMed] [Google Scholar]
- García-López H. L., Rodríguez-Tovar L. E., Medina-De la Garza C. E. Identification of Cyclospora in poultry. Emerg Infect Dis. 1996 Oct-Dec;2(4):356–357. doi: 10.3201/eid0204.960414. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hale D., Aldeen W., Carroll K. Diarrhea associated with Cyanobacterialike bodies in an immunocompetent host. An unusual epidemiological source. JAMA. 1994 Jan 12;271(2):144–145. [PubMed] [Google Scholar]
- Hart A. S., Ridinger M. T., Soundarajan R., Peters C. S., Swiatlo A. L., Kocka F. E. Novel organism associated with chronic diarrhoea in AIDS. Lancet. 1990 Jan 20;335(8682):169–170. doi: 10.1016/0140-6736(90)90042-4. [DOI] [PubMed] [Google Scholar]
- Herwaldt B. L., Ackers M. L. An outbreak in 1996 of cyclosporiasis associated with imported raspberries. The Cyclospora Working Group. N Engl J Med. 1997 May 29;336(22):1548–1556. doi: 10.1056/NEJM199705293362202. [DOI] [PubMed] [Google Scholar]
- Hoge C. W., Shlim D. R., Ghimire M., Rabold J. G., Pandey P., Walch A., Rajah R., Gaudio P., Echeverria P. Placebo-controlled trial of co-trimoxazole for Cyclospora infections among travellers and foreign residents in Nepal. Lancet. 1995 Mar 18;345(8951):691–693. doi: 10.1016/s0140-6736(95)90868-4. [DOI] [PubMed] [Google Scholar]
- Madico G., McDonald J., Gilman R. H., Cabrera L., Sterling C. R. Epidemiology and treatment of Cyclospora cayetanensis infection in Peruvian children. Clin Infect Dis. 1997 May;24(5):977–981. doi: 10.1093/clinids/24.5.977. [DOI] [PubMed] [Google Scholar]
- Meng J., Doyle M. P. Emerging issues in microbiological food safety. Annu Rev Nutr. 1997;17:255–275. doi: 10.1146/annurev.nutr.17.1.255. [DOI] [PubMed] [Google Scholar]
- Millard P. S., Gensheimer K. F., Addiss D. G., Sosin D. M., Beckett G. A., Houck-Jankoski A., Hudson A. An outbreak of cryptosporidiosis from fresh-pressed apple cider. JAMA. 1994 Nov 23;272(20):1592–1596. [PubMed] [Google Scholar]
- Ortega Y. R., Gilman R. H., Sterling C. R. A new coccidian parasite (Apicomplexa: Eimeriidae) from humans. J Parasitol. 1994 Aug;80(4):625–629. [PubMed] [Google Scholar]
- Ortega Y. R., Nagle R., Gilman R. H., Watanabe J., Miyagui J., Quispe H., Kanagusuku P., Roxas C., Sterling C. R. Pathologic and clinical findings in patients with cyclosporiasis and a description of intracellular parasite life-cycle stages. J Infect Dis. 1997 Dec;176(6):1584–1589. doi: 10.1086/514158. [DOI] [PubMed] [Google Scholar]
- Ortega Y. R., Roxas C. R., Gilman R. H., Miller N. J., Cabrera L., Taquiri C., Sterling C. R. Isolation of Cryptosporidium parvum and Cyclospora cayetanensis from vegetables collected in markets of an endemic region in Peru. Am J Trop Med Hyg. 1997 Dec;57(6):683–686. doi: 10.4269/ajtmh.1997.57.683. [DOI] [PubMed] [Google Scholar]
- Ortega Y. R., Sterling C. R., Gilman R. H., Cama V. A., Díaz F. Cyclospora species--a new protozoan pathogen of humans. N Engl J Med. 1993 May 6;328(18):1308–1312. doi: 10.1056/NEJM199305063281804. [DOI] [PubMed] [Google Scholar]
- Rabold J. G., Hoge C. W., Shlim D. R., Kefford C., Rajah R., Echeverria P. Cyclospora outbreak associated with chlorinated drinking water. Lancet. 1994 Nov 12;344(8933):1360–1361. doi: 10.1016/s0140-6736(94)90716-1. [DOI] [PubMed] [Google Scholar]
- Relman D. A., Schmidt T. M., Gajadhar A., Sogin M., Cross J., Yoder K., Sethabutr O., Echeverria P. Molecular phylogenetic analysis of Cyclospora, the human intestinal pathogen, suggests that it is closely related to Eimeria species. J Infect Dis. 1996 Feb;173(2):440–445. doi: 10.1093/infdis/173.2.440. [DOI] [PubMed] [Google Scholar]
- Smith H. V., Paton C. A., Mitambo M. M., Girdwood R. W. Sporulation of Cyclospora sp. oocysts. Appl Environ Microbiol. 1997 Apr;63(4):1631–1632. doi: 10.1128/aem.63.4.1631-1632.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Soave R. Cyclospora: an overview. Clin Infect Dis. 1996 Sep;23(3):429–437. doi: 10.1093/clinids/23.3.429. [DOI] [PubMed] [Google Scholar]
- Steiner T. S., Thielman N. M., Guerrant R. L. Protozoal agents: what are the dangers for the public water supply? Annu Rev Med. 1997;48:329–340. doi: 10.1146/annurev.med.48.1.329. [DOI] [PubMed] [Google Scholar]
- Sturbaum G. D., Ortega Y. R., Gilman R. H., Sterling C. R., Cabrera L., Klein D. A. Detection of Cyclospora cayetanensis in wastewater. Appl Environ Microbiol. 1998 Jun;64(6):2284–2286. doi: 10.1128/aem.64.6.2284-2286.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wurtz R. Cyclospora: a newly identified intestinal pathogen of humans. Clin Infect Dis. 1994 Apr;18(4):620–623. doi: 10.1093/clinids/18.4.620. [DOI] [PubMed] [Google Scholar]
- Yai L. E., Bauab A. R., Hirschfeld M. P., de Oliveira M. L., Damaceno J. T. The first two cases of Cyclospora in dogs, São Paulo, Brazil. Rev Inst Med Trop Sao Paulo. 1997 May-Jun;39(3):177–179. doi: 10.1590/s0036-46651997000300011. [DOI] [PubMed] [Google Scholar]