Abstract
A mark-recapture longitudinal study of immunoglobulin G (IgG) antibody to Sin Nombre virus (SNV) in rodent populations in western Colorado (1994-results summarized to October 1997) indicates the presence of SNV or a closely related hantavirus at two sites. Most rodents (principally deer mice, Peromyscus maniculatus, and pinyon mice, P. truei) did not persist on the trapping webs much beyond 1 month after first capture. Some persisted more than 1 year, which suggests that even a few infected deer mice could serve as transseasonal reservoirs and mechanisms for over-winter virus maintenance. A positive association between wounds and SNV antibody in adult animals at both sites suggests that when infected rodents in certain populations fight with uninfected rodents, virus amplification occurs. At both sites, male rodents comprised a larger percentage of seropositive mice than recaptured mice, which suggests that male mice contribute more to the SNV epizootic cycle than female mice. In deer mice, IgG antibody prevalence fluctuations were positively associated with population fluctuations. The rates of seroconversion, which in deer mice at both sites occurred mostly during late summer and midwinter, were higher than the seroprevalence, which suggests that the longer deer mice live, the greater the probability they will become infected with SNV.
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Selected References
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- Glass G. E., Childs J. E., Korch G. W., LeDuc J. W. Association of intraspecific wounding with hantaviral infection in wild rats (Rattus norvegicus). Epidemiol Infect. 1988 Oct;101(2):459–472. doi: 10.1017/s0950268800054418. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hutchinson K. L., Rollin P. E., Peters C. J. Pathogenesis of a North American hantavirus, Black Creek Canal virus, in experimentally infected Sigmodon hispidus. Am J Trop Med Hyg. 1998 Jul;59(1):58–65. doi: 10.4269/ajtmh.1998.59.58. [DOI] [PubMed] [Google Scholar]
- Kariwa H., Kimura M., Yoshizumi S., Arikawa J., Yoshimatsu K., Takashima I., Hashimoto N. Modes of Seoul virus infections: persistency in newborn rats and transiency in adult rats. Arch Virol. 1996;141(12):2327–2338. doi: 10.1007/BF01718634. [DOI] [PubMed] [Google Scholar]
- Lee H. W., Lee P. W., Baek L. J., Song C. K., Seong I. W. Intraspecific transmission of Hantaan virus, etiologic agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius. Am J Trop Med Hyg. 1981 Sep;30(5):1106–1112. doi: 10.4269/ajtmh.1981.30.1106. [DOI] [PubMed] [Google Scholar]
- Mills J. N., Ksiazek T. G., Ellis B. A., Rollin P. E., Nichol S. T., Yates T. L., Gannon W. L., Levy C. E., Engelthaler D. M., Davis T. Patterns of association with host and habitat: antibody reactive with Sin Nombre virus in small mammals in the major biotic communities of the southwestern United States. Am J Trop Med Hyg. 1997 Mar;56(3):273–284. doi: 10.4269/ajtmh.1997.56.273. [DOI] [PubMed] [Google Scholar]
- Parmenter C. A., Yates T. L., Parmenter R. R., Mills J. N., Childs J. E., Campbell M. L., Dunnum J. L., Milner J. Small mammal survival and trapability in mark-recapture monitoring programs for hantavirus. J Wildl Dis. 1998 Jan;34(1):1–12. doi: 10.7589/0090-3558-34.1.1. [DOI] [PubMed] [Google Scholar]
- Yanagihara R., Amyx H. L., Gajdusek D. C. Experimental infection with Puumala virus, the etiologic agent of nephropathia epidemica, in bank voles (Clethrionomys glareolus). J Virol. 1985 Jul;55(1):34–38. doi: 10.1128/jvi.55.1.34-38.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]