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. 1999 Jan-Feb;5(1):75–86. doi: 10.3201/eid0501.990109

Genetic diversity and distribution of Peromyscus-borne hantaviruses in North America.

M C Monroe 1, S P Morzunov 1, A M Johnson 1, M D Bowen 1, H Artsob 1, T Yates 1, C J Peters 1, P E Rollin 1, T G Ksiazek 1, S T Nichol 1
PMCID: PMC2627704  PMID: 10081674

Abstract

The 1993 outbreak of hantavirus pulmonary syndrome (HPS) in the southwestern United States was associated with Sin Nombre virus, a rodent-borne hantavirus; The virus' primary reservoir is the deer mouse (Peromyscus maniculatus). Hantavirus-infected rodents were identified in various regions of North America. An extensive nucleotide sequence database of an 139 bp fragment amplified from virus M genomic segments was generated. Phylogenetic analysis confirmed that SNV-like hantaviruses are widely distributed in Peromyscus species rodents throughout North America. Classic SNV is the major cause of HPS in North America, but other Peromyscine-borne hantaviruses, e.g., New York and Monongahela viruses, are also associated with HPS cases. Although genetically diverse, SNV-like viruses have slowly coevolved with their rodent hosts. We show that the genetic relationships of hantaviruses in the Americas are complex, most likely as a result of the rapid radiation and speciation of New World sigmodontine rodents and occasional virus-host switching events.

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Selected References

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