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. 1993 Feb;31(2):454–457. doi: 10.1128/jcm.31.2.454-457.1993

Immune response against lipopolysaccharide and invasion plasmid-coded antigens of shigellae in Vietnamese and Swedish dysenteric patients.

P D Cam 1, T Pál 1, A A Lindberg 1
PMCID: PMC262788  PMID: 8432838

Abstract

The peripheral immune responses of adult Vietnamese patients infected with Shigella dysenteriae 1 and Shigella flexneri 1b and 2a and those of S. flexneri-infected Swedish patients were studied against various lipopolysaccharide and invasion plasmid-coded antigens (Ipa-s) and compared with the titers for the corresponding local healthy populations. Both Vietnamese and Swedish patients reacted with significant (P, < 0.05) titer increases in the immunoglobulin A and G classes against the homologous lipopolysaccharide antigen. However, significant titer responses against the Ipa-s were seen among only the Swedish patients. We surmise that the weak-to-moderate responses against the Ipa-s in Vietnamese patients are due to the fact that the high level of titers induced by previous infections in the local population could not be considerably increased further by a recent infection.

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Selected References

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