Abstract
An immunocompetent patient was dually infected with a resistant and a multidrug-resistant strain of Mycobacterium tuberculosis (TB). The multidrug-resistant strain, which belongs to the W- strain/Beijing family, was first isolated after 3 months of therapy. Inappropriate treatment led to further drug resistance and unsuccessful therapy. Thus, additional infections with resistant M. tuberculosis strains should be considered when tuberculosis therapy fails.
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- Glynn J. R., Jenkins P. A., Fine P. E., Pönnighaus J. M., Sterne J. A., Mkandwire P. K., Nyasulu S., Bliss L., Warndorff D. K. Patterns of initial and acquired antituberculosis drug resistance in Karonga District, Malawi. Lancet. 1995 Apr 8;345(8954):907–910. doi: 10.1016/s0140-6736(95)90016-0. [DOI] [PubMed] [Google Scholar]
- Horn D. L., Hewlett D., Jr, Haas W. H., Butler W. R., Alfalla C., Tan E., Levine A., Nayak A., Opal S. M. Superinfection with rifampin-isoniazid-streptomycin-ethambutol (RISE)-resistant tuberculosis in three patients with AIDS: confirmation by polymerase chain reaction fingerprinting. Ann Intern Med. 1994 Jul 15;121(2):115–116. doi: 10.7326/0003-4819-121-2-199407150-00007. [DOI] [PubMed] [Google Scholar]
- Kamerbeek J., Schouls L., Kolk A., van Agterveld M., van Soolingen D., Kuijper S., Bunschoten A., Molhuizen H., Shaw R., Goyal M. Simultaneous detection and strain differentiation of Mycobacterium tuberculosis for diagnosis and epidemiology. J Clin Microbiol. 1997 Apr;35(4):907–914. doi: 10.1128/jcm.35.4.907-914.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Moss A. R., Alland D., Telzak E., Hewlett D., Jr, Sharp V., Chiliade P., LaBombardi V., Kabus D., Hanna B., Palumbo L. A city-wide outbreak of a multiple-drug-resistant strain of Mycobacterium tuberculosis in New York. Int J Tuberc Lung Dis. 1997 Apr;1(2):115–121. [PubMed] [Google Scholar]
- Niemann S., Richter E., Rüsch-Gerdes S. Stability of Mycobacterium tuberculosis IS6110 restriction fragment length polymorphism patterns and spoligotypes determined by analyzing serial isolates from patients with drug-resistant tuberculosis. J Clin Microbiol. 1999 Feb;37(2):409–412. doi: 10.1128/jcm.37.2.409-412.1999. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Niemann S., Rüsch-Gerdes S., Richter E. IS6110 fingerprinting of drug-resistant Mycobacterium tuberculosis strains isolated in Germany during 1995. J Clin Microbiol. 1997 Dec;35(12):3015–3020. doi: 10.1128/jcm.35.12.3015-3020.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pablos-Méndez A., Raviglione M. C., Laszlo A., Binkin N., Rieder H. L., Bustreo F., Cohn D. L., Lambregts-van Weezenbeek C. S., Kim S. J., Chaulet P. Global surveillance for antituberculosis-drug resistance, 1994-1997. World Health Organization-International Union against Tuberculosis and Lung Disease Working Group on Anti-Tuberculosis Drug Resistance Surveillance. N Engl J Med. 1998 Jun 4;338(23):1641–1649. doi: 10.1056/NEJM199806043382301. [DOI] [PubMed] [Google Scholar]
- Shafer R. W., Singh S. P., Larkin C., Small P. M. Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in an immunocompetent patient. Tuber Lung Dis. 1995 Dec;76(6):575–577. doi: 10.1016/0962-8479(95)90537-5. [DOI] [PubMed] [Google Scholar]
- Small P. M., Shafer R. W., Hopewell P. C., Singh S. P., Murphy M. J., Desmond E., Sierra M. F., Schoolnik G. K. Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in patients with advanced HIV infection. N Engl J Med. 1993 Apr 22;328(16):1137–1144. doi: 10.1056/NEJM199304223281601. [DOI] [PubMed] [Google Scholar]
- Theisen A., Reichel C., Rüsch-Gerdes S., Haas W. H., Rockstroh J. K., Spengler U., Sauerbruch T. Mixed-strain infection with a drug-sensitive and multidrug-resistant strain of Mycobacterium tuberculosis. Lancet. 1995 Jun 10;345(8963):1512–1512. doi: 10.1016/s0140-6736(95)91073-5. [DOI] [PubMed] [Google Scholar]
- van Soolingen D., Qian L., de Haas P. E., Douglas J. T., Traore H., Portaels F., Qing H. Z., Enkhsaikan D., Nymadawa P., van Embden J. D. Predominance of a single genotype of Mycobacterium tuberculosis in countries of east Asia. J Clin Microbiol. 1995 Dec;33(12):3234–3238. doi: 10.1128/jcm.33.12.3234-3238.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]