Skip to main content
Emerging Infectious Diseases logoLink to Emerging Infectious Diseases
. 2000 Sep-Oct;6(5):526–529. doi: 10.3201/eid0605.000512

Pertussis infection in fully vaccinated children in day-care centers, Israel.

I Srugo 1, D Benilevi 1, R Madeb 1, S Shapiro 1, T Shohat 1, E Somekh 1, Y Rimmar 1, V Gershtein 1, R Gershtein 1, E Marva 1, N Lahat 1
PMCID: PMC2627963  PMID: 10998384

Abstract

We tested 46 fully vaccinated children in two day-care centers in Israel who were exposed to a fatal case of pertussis infection. Only two of five children who tested positive for Bordetella pertussis met the World Health Organization's case definition for pertussis. Vaccinated children may be asymptomatic reservoirs for infection.

Full Text

The Full Text of this article is available as a PDF (27.8 KB).

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aoyama T., Takeuchi Y., Goto A., Iwai H., Murase Y., Iwata T. Pertussis in adults. Am J Dis Child. 1992 Feb;146(2):163–166. doi: 10.1001/archpedi.1992.02160140029015. [DOI] [PubMed] [Google Scholar]
  2. Baron S., Njamkepo E., Grimprel E., Begue P., Desenclos J. C., Drucker J., Guiso N. Epidemiology of pertussis in French hospitals in 1993 and 1994: thirty years after a routine use of vaccination. Pediatr Infect Dis J. 1998 May;17(5):412–418. doi: 10.1097/00006454-199805000-00013. [DOI] [PubMed] [Google Scholar]
  3. Cherry J. D. The epidemiology of pertussis and pertussis immunization in the United Kingdom and the United States: a comparative study. Curr Probl Pediatr. 1984 Feb;14(2):1–78. doi: 10.1016/0045-9380(84)90016-1. [DOI] [PubMed] [Google Scholar]
  4. Christie C. D., Marx M. L., Marchant C. D., Reising S. F. The 1993 epidemic of pertussis in Cincinnati. Resurgence of disease in a highly immunized population of children. N Engl J Med. 1994 Jul 7;331(1):16–21. doi: 10.1056/NEJM199407073310104. [DOI] [PubMed] [Google Scholar]
  5. Cromer B. A., Goydos J., Hackell J., Mezzatesta J., Dekker C., Mortimer E. A. Unrecognized pertussis infection in adolescents. Am J Dis Child. 1993 May;147(5):575–577. doi: 10.1001/archpedi.1993.02160290081031. [DOI] [PubMed] [Google Scholar]
  6. Fine P. E., Clarkson J. A. The recurrence of whooping cough: possible implications for assessment of vaccine efficacy. Lancet. 1982 Mar 20;1(8273):666–669. doi: 10.1016/s0140-6736(82)92214-0. [DOI] [PubMed] [Google Scholar]
  7. Grimprel E., Baron S., Lévy-Bruhl D., Garnier J. M., N'jamkepo E., Guiso N., Bégué P. Influence of vaccination coverage on pertussis transmission in France. Lancet. 1999 Nov 13;354(9191):1699–1700. doi: 10.1016/S0140-6736(99)01576-7. [DOI] [PubMed] [Google Scholar]
  8. He Q., Mertsola J., Soini H., Skurnik M., Ruuskanen O., Viljanen M. K. Comparison of polymerase chain reaction with culture and enzyme immunoassay for diagnosis of pertussis. J Clin Microbiol. 1993 Mar;31(3):642–645. doi: 10.1128/jcm.31.3.642-645.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. He Q., Mertsola J., Soini H., Viljanen M. K. Sensitive and specific polymerase chain reaction assays for detection of Bordetella pertussis in nasopharyngeal specimens. J Pediatr. 1994 Mar;124(3):421–426. doi: 10.1016/s0022-3476(94)70365-5. [DOI] [PubMed] [Google Scholar]
  10. Lichtinghagen R., Diedrich-Glaubitz R., von Hörsten B. Identification of Bordetella pertussis in nasopharyngeal swabs using the polymerase chain reaction: evaluation of detection methods. Eur J Clin Chem Clin Biochem. 1994 Mar;32(3):161–167. doi: 10.1515/cclm.1994.32.3.161. [DOI] [PubMed] [Google Scholar]
  11. Long S. S., Welkon C. J., Clark J. L. Widespread silent transmission of pertussis in families: antibody correlates of infection and symptomatology. J Infect Dis. 1990 Mar;161(3):480–486. doi: 10.1093/infdis/161.3.480. [DOI] [PubMed] [Google Scholar]
  12. Nelson J. D. The changing epidemiology of pertussis in young infants. The role of adults as reservoirs of infection. Am J Dis Child. 1978 Apr;132(4):371–373. doi: 10.1001/archpedi.1978.02120290043006. [DOI] [PubMed] [Google Scholar]
  13. Rosenthal S., Strebel P., Cassiday P., Sanden G., Brusuelas K., Wharton M. Pertussis infection among adults during the 1993 outbreak in Chicago. J Infect Dis. 1995 Jun;171(6):1650–1652. doi: 10.1093/infdis/171.6.1650. [DOI] [PubMed] [Google Scholar]
  14. Tran Minh N. N., He Q., Edelman K., Olander R. M., Viljanen M. K., Arvilommi H., Mertsola J. Cell-mediated immune responses to antigens of Bordetella pertussis and protection against pertussis in school children. Pediatr Infect Dis J. 1999 Apr;18(4):366–370. doi: 10.1097/00006454-199904000-00012. [DOI] [PubMed] [Google Scholar]
  15. Yaari E., Yafe-Zimerman Y., Schwartz S. B., Slater P. E., Shvartzman P., Andoren N., Branski D., Kerem E. Clinical manifestations of Bordetella pertussis infection in immunized children and young adults. Chest. 1999 May;115(5):1254–1258. doi: 10.1378/chest.115.5.1254. [DOI] [PubMed] [Google Scholar]
  16. de Melker H. E., Conyn-van Spaendonck M. A., Rümke H. C., van Wijngaarden J. K., Mooi F. R., Schellekens J. F. Pertussis in The Netherlands: an outbreak despite high levels of immunization with whole-cell vaccine. Emerg Infect Dis. 1997 Apr-Jun;3(2):175–178. doi: 10.3201/eid0302.970211. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Emerging Infectious Diseases are provided here courtesy of Centers for Disease Control and Prevention

RESOURCES