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Emerging Infectious Diseases logoLink to Emerging Infectious Diseases
. 2000 Jan-Feb;6(1):36–41. doi: 10.3201/eid0601.000106

Norwalk-like calicivirus genes in farm animals.

W H van Der Poel 1, J Vinjé 1, R van Der Heide 1, M I Herrera 1, A Vivo 1, M P Koopmans 1
PMCID: PMC2627973  PMID: 10653567

Abstract

Viruses closely related to Norwalk-like viruses (NLVs) were recently found in stored stool samples from two calves (United Kingdom and Germany) and four pigs (Japan), sparking discussions about the potential for zoonotic transmission. To investigate if NLVs are commonly present in farm animals, pooled stool samples from 100 pig farms, 48 chicken farms, 43 dairy cow herds, and 75 veal calf farms from the Netherlands were assayed by reverse transcription- polymerase chain reaction amplification, using primers specific for the detection of NLVs from humans. NLV RNA was detected in 33 (44%) of the specimens from veal calf farms and two (2%) specimens from pig farms. Our data show that NLV infections until recently thought to be restricted to humans occur often in calves and sometimes in pigs. While zoonotic transmission has not been proven, these findings suggest that calves and pigs may be reservoir hosts of NLVs.

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Selected References

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  1. Ando T., Mulders M. N., Lewis D. C., Estes M. K., Monroe S. S., Glass R. I. Comparison of the polymerase region of small round structured virus strains previously classified in three antigenic types by solid-phase immune electron microscopy. Arch Virol. 1994;135(1-2):217–226. doi: 10.1007/BF01309781. [DOI] [PubMed] [Google Scholar]
  2. Bridger J. C., Hall G. A., Brown J. F. Characterization of a calici-like virus (Newbury agent) found in association with astrovirus in bovine diarrhea. Infect Immun. 1984 Jan;43(1):133–138. doi: 10.1128/iai.43.1.133-138.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Flewett T. H. Electron microscopy in the diagnosis of infectious diarrhea. J Am Vet Med Assoc. 1978 Sep 1;173(5 Pt 2):538–543. [PubMed] [Google Scholar]
  4. Green K. Y. The role of human caliciviruses in epidemic gastroenteritis. Arch Virol Suppl. 1997;13:153–165. doi: 10.1007/978-3-7091-6534-8_15. [DOI] [PubMed] [Google Scholar]
  5. Hashimoto M., Roerink F., Tohya Y., Mochizuki M. Genetic analysis of the RNA polymerase gene of caliciviruses from dogs and cats. J Vet Med Sci. 1999 Jun;61(6):603–608. doi: 10.1292/jvms.61.603. [DOI] [PubMed] [Google Scholar]
  6. Jiang X., Cubitt W. D., Berke T., Zhong W., Dai X., Nakata S., Pickering L. K., Matson D. O. Sapporo-like human caliciviruses are genetically and antigenically diverse. Arch Virol. 1997;142(9):1813–1827. doi: 10.1007/s007050050199. [DOI] [PubMed] [Google Scholar]
  7. Liu B. L., Lambden P. R., Günther H., Otto P., Elschner M., Clarke I. N. Molecular characterization of a bovine enteric calicivirus: relationship to the Norwalk-like viruses. J Virol. 1999 Jan;73(1):819–825. doi: 10.1128/jvi.73.1.819-825.1999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Matson D. O., Zhong W. M., Nakata S., Numata K., Jiang X., Pickering L. K., Chiba S., Estes M. K. Molecular characterization of a human calicivirus with sequence relationships closer to animal caliciviruses than other known human caliciviruses. J Med Virol. 1995 Feb;45(2):215–222. doi: 10.1002/jmv.1890450218. [DOI] [PubMed] [Google Scholar]
  9. Noel J. S., Fankhauser R. L., Ando T., Monroe S. S., Glass R. I. Identification of a distinct common strain of "Norwalk-like viruses" having a global distribution. J Infect Dis. 1999 Jun;179(6):1334–1344. doi: 10.1086/314783. [DOI] [PubMed] [Google Scholar]
  10. Pringle C. R. Virus taxonomy--San Diego 1998. Arch Virol. 1998;143(7):1449–1459. doi: 10.1007/s007050050389. [DOI] [PubMed] [Google Scholar]
  11. Reynolds D. J., Morgan J. H., Chanter N., Jones P. W., Bridger J. C., Debney T. G., Bunch K. J. Microbiology of calf diarrhoea in southern Britain. Vet Rec. 1986 Jul 12;119(2):34–39. doi: 10.1136/vr.119.2.34. [DOI] [PubMed] [Google Scholar]
  12. Smith A. W., Akers T. G. Vesicular exanthema of swine. J Am Vet Med Assoc. 1976 Oct 1;169(7):700–703. [PubMed] [Google Scholar]
  13. Smith A. W., Skilling D. E., Cherry N., Mead J. H., Matson D. O. Calicivirus emergence from ocean reservoirs: zoonotic and interspecies movements. Emerg Infect Dis. 1998 Jan-Mar;4(1):13–20. doi: 10.3201/eid0401.980103. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sugieda M., Nagaoka H., Kakishima Y., Ohshita T., Nakamura S., Nakajima S. Detection of Norwalk-like virus genes in the caecum contents of pigs. Arch Virol. 1998;143(6):1215–1221. doi: 10.1007/s007050050369. [DOI] [PubMed] [Google Scholar]
  15. Vinjé J., Koopmans M. P. Molecular detection and epidemiology of small round-structured viruses in outbreaks of gastroenteritis in the Netherlands. J Infect Dis. 1996 Sep;174(3):610–615. doi: 10.1093/infdis/174.3.610. [DOI] [PubMed] [Google Scholar]
  16. Will L. A., Paul P. S., Proescholdt T. A., Aktar S. N., Flaming K. P., Janke B. H., Sacks J., Lyoo Y. S., Hill H. T., Hoffman L. J. Evaluation of rotavirus infection and diarrhea in Iowa commercial pigs based on an epidemiologic study of a population represented by diagnostic laboratory cases. J Vet Diagn Invest. 1994 Oct;6(4):416–422. doi: 10.1177/104063879400600403. [DOI] [PubMed] [Google Scholar]

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