Fig. 8.

Relationship between PGE-2, TNF-α, IL-1β, Aβ levels and spatial reference memory inTg2576 mice. (a) 13-month transgene positive Tg2576 mice (Tg⁺) on NSAID or control diets were divided into three evenly sized bins based upon performance in the water maze (low, medium and high MPS categories). There was a significant effect of MPS category in both control and NSAID-treated mice (P<0.001 and P<0.0001, respectively. a:b, b:c, a:c within control and NSAID treatment groups represent significant Fisher’s PLSD post hoc comparisons. *P<0.01 by unpaired t-test.) (b) There was an inverse relationship between water maze performance (MPS) and cortical PGE-2 levels in NSAID-treated mice (P<0.05). *P<0.01 by Fisher’s PLSD. No relationship between MPS and PGE-2 levels was observed in mice receiving Control diet. (c–f) No relationship was observed between MPS and hippocampal TNF-α, hippocampal IL-1β, cortical total Aβ40 or cortical total Aβ42 respectively in control or NSAID-treated mice. Data are means ± SEM. Numbers of mice denoted inside bars.