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. 2008 Nov 3;113(4):929–935. doi: 10.1182/blood-2008-07-167775

Figure 4.

Figure 4

N-glycans affect the VWF cleaving activity of ADAMTS13. (A) The mean VWF cleaving activity (± SD) from 4 measurements is depicted for WT ADAMTS13, AD5, and AD2 in CHO or Lec1 cell secretion. The insert is a magnification of the AD2 results. *P < .05 by Student t test. (B) VWF cleaving activity of WT ADAMTS13 and 8 N-residue mutants. ADAMTS13 proteins were from secretion of HEK 293T cells. For each mutant, the VWF cleaving activity level per nanomole protein is expressed as a percentage of WT ADAMTS13. *P < .01 by ANOVA with Dunnett posttest against the WT ADAMTS13 (N = 4-6).