Table 2.

Allelic associations with PD using APL and PDT in the overall, early-onset, and late-onset families with sporadic PD using an AAO cutoff of 40 years. Significant results (p≤0.05) are highlighted in bold.

			Overall (N=337 families)		Early-onset (N=40 families)		Late-onset (N=297 families)
Gene and SNP	SNP type	Alleles (frequency)	APL p	PDT p	APL p	PDT p	APL p	PDT p
NOS1:
rs3782221	intronic	A(0.22)/G(0.78)	0.89	0.40	0.60	1.00	0.83	0.33
rs1123425	intronic	A(0.56)/G(0.44)	0.71	0.87	0.83	0.89	0.82	0.81
rs693534	intronic	A(0.39)/G(0.61)	0.23	0.82	0.13	0.058	0.63	0.58
rs1552228	intronic	A(0.88)/G(0.12)	0.71	0.78	0.64	0.47	0.63	1.00
rs1552227	intronic	C(0.72)/T(0.28)	0.74	0.89	0.16	0.12	0.31	0.26
rs545654	intronic	C(0.48)/T(0.52)	0.48	1.00	0.089	0.14	0.98	0.47
rs3782218	intronic	C(0.82)/T(0.18)	0.93	0.82	0.11	0.12	0.61	0.54
rs1520811	intronic	A(0.31)/G(0.69)	0.63	0.95	0.32	0.19	0.40	0.69
rs12578547	intronic	C(0.22)/T(0.78)	0.79	1.00	0.15	0.43	0.90	0.74
rs1483757	intronic	A(0.58)/G(0.42)	0.74	0.90	0.17	0.10	0.35	0.60
rs547954	intronic	A(0.18)/G(0.82)	0.75	0.75	0.79	0.58	0.92	0.53
rs561712	intronic	C(0.61)/T(0.39)	0.93	0.91	0.33	0.26	0.62	0.69
rs478597	intronic	C(0.61)/T(0.39)	0.99	0.95	0.29	0.29	0.55	0.65
rs11068447	intronic	A(0.10)/G(0.90)	0.23	0.70	0.86	0.68	0.25	0.51
rs7295972	intronic	A(0.51)/G(0.49)	0.36	0.51	0.12	0.15	0.72	0.95
rs11611788	intronic	A(0.89)/G(0.11)	0.32	0.44	0.97	0.85	0.27	0.43
rs2293052	intronic	A(0.37)/G(0.63)	0.18	0.28	0.066	0.090	0.56	0.69
rs7139256	intronic	C(0.21)/T(0.79)	0.34	1.00	0.55	0.58	0.49	0.79
rs2293055	intronic	A(0.08)/G(0.92)	0.48	1.00	0.71	0.34	0.36	0.54
rs2293054	synonymous coding	A(0.30)/G(0.70)	0.17	0.68	0.66	0.63	0.24	0.82
rs12829185	intronic	C(0.81)/T(0.19)	0.076	0.24	0.046	0.059	0.35	0.67
rs1047735	synonymous coding	A(0.29)/G(0.71)	0.25	0.41	0.31	0.35	0.44	0.61
rs816354	intronic	C(0.08)/T(0.92)	0.73	0.70	0.30	0.18	0.49	0.83
rs10774910	intronic	C(0.69)/T(0.31)	0.11	0.085	0.75	0.49	0.13	0.11
rs4767523	intronic	G(0.09)/T(0.91)	0.95	1.00	0.40	0.74	0.88	0.90
rs3741475	synonymous coding	A(0.20)/G(0.80)	0.10	0.24	0.025	0.025	0.43	0.72
rs2682826	3′ untranslated	A(0.27)/G(0.73)	0.26	0.17	0.036	0.035	0.67	0.61
NOS2A:
rs3730014	synonymous coding	A(0.02)/G(0.98)	0.40	0.64	0.90	0.56	0.24	0.44
rs3794766	intronic	C(0.76)/T(0.24)	0.45	0.43	0.82	0.41	0.46	0.68
rs2072324	intronic	A(0.19)/C(0.81)	0.17	0.047	0.15	0.39	0.42	0.073
rs8072199	intronic	C(0.55)/T(0.45)	0.39	0.42	0.44	0.65	0.27	0.29
rs16966563	synonymous coding	C(0.02)/T(0.98)	0.26	0.23	0.80	1.00	0.18	0.17
rs3794764	intronic	A(0.20)/G(0.80)	0.17	0.047	0.21	0.35	0.29	0.077
rs17722851	intronic	A(0.10)/T(0.90)	0.34	0.50	0.31	0.25	0.13	0.22
rs944725	intronic	C(0.63)/T(0.37)	0.094	0.12	0.090	0.37	0.26	0.18
rs4795067	intronic	A(0.68)/G(0.32)	0.43	0.33	0.25	0.49	0.16	0.17
rs1137933	synonymous coding	A(0.22)/G(0.78)	0.90	0.94	0.81	0.53	0.92	0.86
rs12944039	intronic	A(0.20)/G(0.80)	0.014	0.0007	0.000018	0.0023	0.37	0.025
rs2314810	intronic	C(0.06)/G(0.94)	0.38	0.17	0.32	0.48	0.59	0.22
rs2248814	intronic	A(0.42)/G(0.58)	0.60	0.51	0.0036	0.059	0.61	1.00
rs2297518	non-synonymous coding	A(0.20)/G(0.80)	0.89	0.53	0.65	0.67	0.76	0.40
rs2297516	intronic	A(0.64)/C(0.36)	0.062	0.038	0.000004	0.0023	0.73	0.36
rs2297515	intronic	A(0.86)/C(0.14)	0.30	0.53	0.72	0.47	0.40	0.70
rs1060826	synonymous coding	A(0.41)/G(0.59)	0.47	0.56	0.0098	0.096	0.83	0.94
rs2255929	intronic	A(0.41)/T(0.59)	0.043	0.066	0.000036	0.0027	0.57	0.50
NOS3:
rs1800783	intronic	A(0.41)/T(0.59)	0.12	0.42	0.062	0.45	0.38	0.60
rs1549758	synonymous coding	C(0.68)/T(0.32)	0.79	0.23	0.71	0.50	0.48	0.32
rs1799983	non-synonymous coding	G(0.66)/T(0.34)	0.92	0.14	0.98	0.24	0.88	0.29
rs3918227	intronic	A(0.09)/C(0.91)	0.11	0.15	0.16	0.13	0.30	0.38
rs1808593	intronic	A(0.75)/C(0.25)	0.17	0.90	0.16	0.52	0.46	0.83