Figure 5. Mice given levofloxacin at 24 hours post-infection are immune to subsequent challenge with SCHU S4.

Mice were infected via intra-nasal challenge (90 CFU) and treated with varying concentrations of levofloxacin at 24 hours post-infection as described in Figure 1. At 24 hours post-infection, mice were divided into groups (ten mice per group) and given one of the following doses of levofloxacin: 6.25, 12.50, 25, or 50 mg/kg body weight. Mice were then housed for 50 days, and then challenged intra-nasally with 3 LD₅₀ doses of SCHU S4. Mice (10 per group) were monitored twice daily for up to one month. Asterisk indicates statistically significant survival with p<0.0007