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. 2001 Jan-Feb;7(1):146–148. doi: 10.3201/eid0701.700146

Pathologic studies of fatal cases in outbreak of hand, foot, and mouth disease, Taiwan.

W J Shieh 1, S M Jung 1, C Hsueh 1, T T Kuo 1, A Mounts 1, U Parashar 1, C F Yang 1, J Guarner 1, T G Ksiazek 1, J Dawson 1, C Goldsmith 1, G J Chang 1, S M Oberste 1, M A Pallansch 1, L J Anderson 1, S R Zaki 1
PMCID: PMC2631691  PMID: 11266307

Abstract

In 1998, an outbreak of enterovirus 71-associated hand, foot, and mouth disease occurred in Taiwan. Pathologic studies of two fatal cases with similar clinical features revealed two different causative agents, emphasizing the need for postmortem examinations and modern pathologic techniques in an outbreak investigation.

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Selected References

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  1. Centers for Disease Control and Prevention (CDC) Deaths among children during an outbreak of hand, foot, and mouth disease--Taiwan, Republic of China, April-July 1998. MMWR Morb Mortal Wkly Rep. 1998 Aug 7;47(30):629–632. [PubMed] [Google Scholar]
  2. Centers for Disease Control and Prevention (CDC) Outbreak of Hendra-like virus--Malaysia and Singapore, 1998-1999. MMWR Morb Mortal Wkly Rep. 1999 Apr 9;48(13):265–269. [PubMed] [Google Scholar]
  3. Centers for Disease Control and Prevention (CDC) Outbreak of West Nile-like viral encephalitis--New York, 1999. MMWR Morb Mortal Wkly Rep. 1999 Oct 1;48(38):845–849. [PubMed] [Google Scholar]
  4. Chang L. Y., Huang Y. C., Lin T. Y. Fulminant neurogenic pulmonary oedema with hand, foot, and mouth disease. Lancet. 1998 Aug 1;352(9125):367–368. doi: 10.1016/S0140-6736(98)24031-1. [DOI] [PubMed] [Google Scholar]
  5. Chua K. B., Bellini W. J., Rota P. A., Harcourt B. H., Tamin A., Lam S. K., Ksiazek T. G., Rollin P. E., Zaki S. R., Shieh W. Nipah virus: a recently emergent deadly paramyxovirus. Science. 2000 May 26;288(5470):1432–1435. doi: 10.1126/science.288.5470.1432. [DOI] [PubMed] [Google Scholar]
  6. Ho M., Chen E. R., Hsu K. H., Twu S. J., Chen K. T., Tsai S. F., Wang J. R., Shih S. R. An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group. N Engl J Med. 1999 Sep 23;341(13):929–935. doi: 10.1056/NEJM199909233411301. [DOI] [PubMed] [Google Scholar]
  7. Liu C. C., Tseng H. W., Wang S. M., Wang J. R., Su I. J. An outbreak of enterovirus 71 infection in Taiwan, 1998: epidemiologic and clinical manifestations. J Clin Virol. 2000 Jun;17(1):23–30. doi: 10.1016/s1386-6532(00)00068-8. [DOI] [PubMed] [Google Scholar]
  8. Lum L. C., Wong K. T., Lam S. K., Chua K. B., Goh A. Y., Lim W. L., Ong B. B., Paul G., AbuBakar S., Lambert M. Fatal enterovirus 71 encephalomyelitis. J Pediatr. 1998 Dec;133(6):795–798. doi: 10.1016/s0022-3476(98)70155-6. [DOI] [PubMed] [Google Scholar]
  9. Shieh W. J., Guarner J., Layton M., Fine A., Miller J., Nash D., Campbell G. L., Roehrig J. T., Gubler D. J., Zaki S. R. The role of pathology in an investigation of an outbreak of West Nile encephalitis in New York, 1999. Emerg Infect Dis. 2000 Jul-Aug;6(4):370–372. doi: 10.3201/eid0604.000407. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Shindarov L. M., Chumakov M. P., Voroshilova M. K., Bojinov S., Vasilenko S. M., Iordanov I., Kirov I. D., Kamenov E., Leshchinskaya E. V., Mitov G. Epidemiological, clinical, and pathomorphological characteristics of epidemic poliomyelitis-like disease caused by enterovirus 71. J Hyg Epidemiol Microbiol Immunol. 1979;23(3):284–295. [PubMed] [Google Scholar]
  11. Zaki S. R., Shieh W. J. Leptospirosis associated with outbreak of acute febrile illness and pulmonary haemorrhage, Nicaragua, 1995. The Epidemic Working Group at Ministry of Health in Nicaragua. Lancet. 1996 Feb 24;347(9000):535–536. doi: 10.1016/s0140-6736(96)91167-8. [DOI] [PubMed] [Google Scholar]

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