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. 2001 Mar-Apr;7(2):174–177. doi: 10.3201/eid0702.010203

The impact of hospital-acquired bloodstream infections.

R P Wenzel 1, M B Edmond 1
PMCID: PMC2631709  PMID: 11294700

Abstract

Nosocomial bloodstream infections are a leading cause of death in the United States. If we assume a nosocomial infection rate of 5%, of which 10% are bloodstream infections, and an attributable mortality rate of 15%, bloodstream infections would represent the eighth leading cause of death in the United States. Because most risk factors for dying after bacteremia or fungemia may not be changeable, prevention efforts must focus on new infection-control technology and techniques.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bischoff W. E., Reynolds T. M., Sessler C. N., Edmond M. B., Wenzel R. P. Handwashing compliance by health care workers: The impact of introducing an accessible, alcohol-based hand antiseptic. Arch Intern Med. 2000 Apr 10;160(7):1017–1021. doi: 10.1001/archinte.160.7.1017. [DOI] [PubMed] [Google Scholar]
  2. Broderick A., Mori M., Nettleman M. D., Streed S. A., Wenzel R. P. Nosocomial infections: validation of surveillance and computer modeling to identify patients at risk. Am J Epidemiol. 1990 Apr;131(4):734–742. doi: 10.1093/oxfordjournals.aje.a115558. [DOI] [PubMed] [Google Scholar]
  3. Darouiche R. O., Raad I. I., Heard S. O., Thornby J. I., Wenker O. C., Gabrielli A., Berg J., Khardori N., Hanna H., Hachem R. A comparison of two antimicrobial-impregnated central venous catheters. Catheter Study Group. N Engl J Med. 1999 Jan 7;340(1):1–8. doi: 10.1056/NEJM199901073400101. [DOI] [PubMed] [Google Scholar]
  4. Doebbeling B. N., Stanley G. L., Sheetz C. T., Pfaller M. A., Houston A. K., Annis L., Li N., Wenzel R. P. Comparative efficacy of alternative hand-washing agents in reducing nosocomial infections in intensive care units. N Engl J Med. 1992 Jul 9;327(2):88–93. doi: 10.1056/NEJM199207093270205. [DOI] [PubMed] [Google Scholar]
  5. Edmond M. B., Wallace S. E., McClish D. K., Pfaller M. A., Jones R. N., Wenzel R. P. Nosocomial bloodstream infections in United States hospitals: a three-year analysis. Clin Infect Dis. 1999 Aug;29(2):239–244. doi: 10.1086/520192. [DOI] [PubMed] [Google Scholar]
  6. Haley R. W., Culver D. H., White J. W., Morgan W. M., Emori T. G., Munn V. P., Hooton T. M. The efficacy of infection surveillance and control programs in preventing nosocomial infections in US hospitals. Am J Epidemiol. 1985 Feb;121(2):182–205. doi: 10.1093/oxfordjournals.aje.a113990. [DOI] [PubMed] [Google Scholar]
  7. Morrison A. J., Jr, Kaiser D. L., Wenzel R. P. A measurement of the efficacy of nosocomial infection control using the 95 per cent confidence interval for infection rates. Am J Epidemiol. 1987 Aug;126(2):292–297. doi: 10.1093/aje/126.2.292. [DOI] [PubMed] [Google Scholar]
  8. Pittet D., Wenzel R. P. Nosocomial bloodstream infections. Secular trends in rates, mortality, and contribution to total hospital deaths. Arch Intern Med. 1995 Jun 12;155(11):1177–1184. doi: 10.1001/archinte.155.11.1177. [DOI] [PubMed] [Google Scholar]
  9. Wenzel R. P., Edmond M. B. The evolving technology of venous access. N Engl J Med. 1999 Jan 7;340(1):48–50. doi: 10.1056/NEJM199901073400109. [DOI] [PubMed] [Google Scholar]
  10. Wenzel R. P., Osterman C. A., Townsend T. R., Veazey J. M., Jr, Servis K. H., Miller L. S., Craven R. B., Miller G. B., Jr, Jackson R. S. Development of a statewide program for surveillance and reporting of hospital-acquired infections. J Infect Dis. 1979 Nov;140(5):741–746. doi: 10.1093/infdis/140.5.741. [DOI] [PubMed] [Google Scholar]
  11. Wenzel R. P. Perspective: Attributable mortality--the promise of better antimicrobial therapy. J Infect Dis. 1998 Sep;178(3):917–919. doi: 10.1086/515379. [DOI] [PubMed] [Google Scholar]
  12. Wenzel R. P. The Lowbury Lecture. The economics of nosocomial infections. J Hosp Infect. 1995 Oct;31(2):79–87. doi: 10.1016/0195-6701(95)90162-0. [DOI] [PubMed] [Google Scholar]
  13. Wenzel R. P. The mortality of hospital-acquired bloodstream infections: need for a new vital statistic? Int J Epidemiol. 1988 Mar;17(1):225–227. doi: 10.1093/ije/17.1.225. [DOI] [PubMed] [Google Scholar]

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