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. 2001 May-Jun;7(3):397–402. doi: 10.3201/eid0703.010305

Transmission of an arenavirus in white-throated woodrats (Neotoma albigula), southeastern Colorado, 1995-1999.

C H Calisher 1, S Nabity 1, J J Root 1, C F Fulhorst 1, B J Beaty 1
PMCID: PMC2631787  PMID: 11384515

Abstract

From 1995 to 1999, we conducted longitudinal studies of white- throated woodrats (Neotoma albigula) in southeastern Colorado. Forty-five (42.9%) of 105 female and 15 (26.8%) of 56 male N. albigula had antibodies against Whitewater Arroyo virus (WWAV). Sixteen female and three male N. albigula seroconverted during the study period, most of them during July-November, when population densities are highest. Analyses of longevity data, minimum numbers alive and infected, movements, and weight data suggest that the dominant mode of WWAV transmission among white-throated woodrats in Colorado is direct contact. WWAV was recently reported to cause fatal infection in humans. Our findings will lead to better assessment of the public health threat posed by infected woodrats and may be useful in predicting periods of increased risk for human infection.

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Selected References

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  1. Calisher C. H., Sweeney W., Mills J. N., Beaty B. J. Natural history of Sin Nombre virus in western Colorado. Emerg Infect Dis. 1999 Jan-Feb;5(1):126–134. doi: 10.3201/eid0501.990115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Calisher C. H., Tzianabos T., Lord R. D., Coleman P. H. Tamiami virus, a new member of the TaCaribe group. Am J Trop Med Hyg. 1970 May;19(3):520–526. doi: 10.4269/ajtmh.1970.19.520. [DOI] [PubMed] [Google Scholar]
  3. Centers for Disease Control and Prevention (CDC) Fatal illnesses associated with a new world arenavirus--California, 1999-2000. MMWR Morb Mortal Wkly Rep. 2000 Aug 11;49(31):709–711. [PubMed] [Google Scholar]
  4. Childs J. E., Ksiazek T. G., Spiropoulou C. F., Krebs J. W., Morzunov S., Maupin G. O., Gage K. L., Rollin P. E., Sarisky J., Enscore R. E. Serologic and genetic identification of Peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States. J Infect Dis. 1994 Jun;169(6):1271–1280. doi: 10.1093/infdis/169.6.1271. [DOI] [PubMed] [Google Scholar]
  5. Feldmann H., Sanchez A., Morzunov S., Spiropoulou C. F., Rollin P. E., Ksiazek T. G., Peters C. J., Nichol S. T. Utilization of autopsy RNA for the synthesis of the nucleocapsid antigen of a newly recognized virus associated with hantavirus pulmonary syndrome. Virus Res. 1993 Dec;30(3):351–367. doi: 10.1016/0168-1702(93)90101-r. [DOI] [PubMed] [Google Scholar]
  6. Fulhorst C. F., Bowen M. D., Ksiazek T. G., Rollin P. E., Nichol S. T., Kosoy M. Y., Peters C. J. Isolation and characterization of Whitewater Arroyo virus, a novel North American arenavirus. Virology. 1996 Oct 1;224(1):114–120. doi: 10.1006/viro.1996.0512. [DOI] [PubMed] [Google Scholar]
  7. Jennings W. L., Lewis A. L., Sather G. E., Pierce L. V., Bond J. O. Tamiami virus in the Tampa Bay area. Am J Trop Med Hyg. 1970 May;19(3):527–536. doi: 10.4269/ajtmh.1970.19.527. [DOI] [PubMed] [Google Scholar]
  8. Kosoy M. Y., Elliott L. H., Ksiazek T. G., Fulhorst C. F., Rollin P. E., Childs J. E., Mills J. N., Maupin G. O., Peters C. J. Prevalence of antibodies to arenaviruses in rodents from the southern and western United States: evidence for an arenavirus associated with the genus Neotoma. Am J Trop Med Hyg. 1996 Jun;54(6):570–576. doi: 10.4269/ajtmh.1996.54.570. [DOI] [PubMed] [Google Scholar]
  9. McClure P. A. Sex-Biased Litter Reduction in Food-Restricted Wood Rats (Neotoma floridana). Science. 1981 Mar 6;211(4486):1058–1060. doi: 10.1126/science.211.4486.1058. [DOI] [PubMed] [Google Scholar]
  10. Mills J. N., Ksiazek T. G., Peters C. J., Childs J. E. Long-term studies of hantavirus reservoir populations in the southwestern United States: a synthesis. Emerg Infect Dis. 1999 Jan-Feb;5(1):135–142. doi: 10.3201/eid0501.990116. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Mills J. N., Yates T. L., Ksiazek T. G., Peters C. J., Childs J. E. Long-term studies of hantavirus reservoir populations in the southwestern United States: rationale, potential, and methods. Emerg Infect Dis. 1999 Jan-Feb;5(1):95–101. doi: 10.3201/eid0501.990111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Mills J. N., Yates T. L., Ksiazek T. G., Peters C. J., Childs J. E. Long-term studies of hantavirus reservoir populations in the southwestern United States: rationale, potential, and methods. Emerg Infect Dis. 1999 Jan-Feb;5(1):95–101. doi: 10.3201/eid0501.990111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Murphy F. A., Winn W. C., Jr, Walker D. H., Flemister M. R., Whitfield S. G. Early lymphoreticular viral tropism and antigen persistence. Tamiami virus infection in the cotton rat. Lab Invest. 1976 Feb;34(2):125–140. [PubMed] [Google Scholar]
  14. Vitullo A. D., Hodara V. L., Merani M. S. Effect of persistent infection with Junin virus on growth and reproduction of its natural reservoir, Calomys musculinus. Am J Trop Med Hyg. 1987 Nov;37(3):663–669. doi: 10.4269/ajtmh.1987.37.663. [DOI] [PubMed] [Google Scholar]
  15. Wolff H., Lange J. V., Webb P. A. Interrelationships among arenaviruses measured by indirect immunofluorescence. Intervirology. 1978;9(6):344–350. doi: 10.1159/000148956. [DOI] [PubMed] [Google Scholar]

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