Abstract
The recent entry of products containing antibacterial agents into healthy households has escalated from a few dozen products in the mid-1990s to more than 700 today. Antibacterial products were developed and have been successfully used to prevent transmission of disease-causing microorganisms among patients, particularly in hospitals. They are now being added to products used in healthy households, even though an added health benefit has not been demonstrated. Scientists are concerned that the antibacterial agents will select bacteria resistant to them and cross-resistant to antibiotics. Moreover, if they alter a person's microflora, they may negatively affect the normal maturation of the T helper cell response of the immune system to commensal flora antigens; this change could lead to a greater chance of allergies in children. As with antibiotics, prudent use of these products is urged. Their designated purpose is to protect vulnerable patients.
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Selected References
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- AKimitsu N., Hamamoto H., Inoue R., Shoji M., Akamine A., Takemori K., Hamasaki N., Sekimizu K. Increase in resistance of methicillin-resistant Staphylococcus aureus to beta-lactams caused by mutations conferring resistance to benzalkonium chloride, a disinfectant widely used in hospitals. Antimicrob Agents Chemother. 1999 Dec;43(12):3042–3043. doi: 10.1128/aac.43.12.3042. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Aaby P., Shaheen S. O., Heyes C. B., Goudiaby A., Hall A. J., Shiell A. W., Jensen H., Marchant A. Early BCG vaccination and reduction in atopy in Guinea-Bissau. Clin Exp Allergy. 2000 May;30(5):644–650. doi: 10.1046/j.1365-2222.2000.00803.x. [DOI] [PubMed] [Google Scholar]
- Alekshun M. N., Levy S. B. The mar regulon: multiple resistance to antibiotics and other toxic chemicals. Trends Microbiol. 1999 Oct;7(10):410–413. doi: 10.1016/s0966-842x(99)01589-9. [DOI] [PubMed] [Google Scholar]
- Barbosa T. M., Levy S. B. Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA. J Bacteriol. 2000 Jun;182(12):3467–3474. doi: 10.1128/jb.182.12.3467-3474.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Braun-Fahrländer C., Gassner M., Grize L., Neu U., Sennhauser F. H., Varonier H. S., Vuille J. C., Wüthrich B. Prevalence of hay fever and allergic sensitization in farmer's children and their peers living in the same rural community. SCARPOL team. Swiss Study on Childhood Allergy and Respiratory Symptoms with Respect to Air Pollution. Clin Exp Allergy. 1999 Jan;29(1):28–34. doi: 10.1046/j.1365-2222.1999.00479.x. [DOI] [PubMed] [Google Scholar]
- Folkerts G., Walzl G., Openshaw P. J. Do common childhood infections 'teach' the immune system not to be allergic? Immunol Today. 2000 Mar;21(3):118–120. doi: 10.1016/s0167-5699(00)01582-6. [DOI] [PubMed] [Google Scholar]
- Heath R. J., Rock C. O. A triclosan-resistant bacterial enzyme. Nature. 2000 Jul 13;406(6792):145–146. doi: 10.1038/35018162. [DOI] [PubMed] [Google Scholar]
- Hoang T. T., Schweizer H. P. Characterization of Pseudomonas aeruginosa enoyl-acyl carrier protein reductase (FabI): a target for the antimicrobial triclosan and its role in acylated homoserine lactone synthesis. J Bacteriol. 1999 Sep;181(17):5489–5497. doi: 10.1128/jb.181.17.5489-5497.1999. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Matricardi P. M., Rosmini F., Riondino S., Fortini M., Ferrigno L., Rapicetta M., Bonini S. Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ. 2000 Feb 12;320(7232):412–417. doi: 10.1136/bmj.320.7232.412. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McMurry L. M., McDermott P. F., Levy S. B. Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan. Antimicrob Agents Chemother. 1999 Mar;43(3):711–713. doi: 10.1128/aac.43.3.711. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McMurry L. M., Oethinger M., Levy S. B. Overexpression of marA, soxS, or acrAB produces resistance to triclosan in laboratory and clinical strains of Escherichia coli. FEMS Microbiol Lett. 1998 Sep 15;166(2):305–309. doi: 10.1111/j.1574-6968.1998.tb13905.x. [DOI] [PubMed] [Google Scholar]
- McMurry L. M., Oethinger M., Levy S. B. Triclosan targets lipid synthesis. Nature. 1998 Aug 6;394(6693):531–532. doi: 10.1038/28970. [DOI] [PubMed] [Google Scholar]
- Mereghetti L., Quentin R., Marquet-Van Der Mee N., Audurier A. Low sensitivity of Listeria monocytogenes to quaternary ammonium compounds. Appl Environ Microbiol. 2000 Nov;66(11):5083–5086. doi: 10.1128/aem.66.11.5083-5086.2000. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Neu H. C. The crisis in antibiotic resistance. Science. 1992 Aug 21;257(5073):1064–1073. doi: 10.1126/science.257.5073.1064. [DOI] [PubMed] [Google Scholar]
- Rook G. A., Stanford J. L. Give us this day our daily germs. Immunol Today. 1998 Mar;19(3):113–116. doi: 10.1016/s0167-5699(97)01204-8. [DOI] [PubMed] [Google Scholar]
- Russell A. D., Tattawasart U., Maillard J. Y., Furr J. R. Possible link between bacterial resistance and use of antibiotics and biocides. Antimicrob Agents Chemother. 1998 Aug;42(8):2151–2151. doi: 10.1128/aac.42.8.2151. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Strachan D. P. Hay fever, hygiene, and household size. BMJ. 1989 Nov 18;299(6710):1259–1260. doi: 10.1136/bmj.299.6710.1259. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Suller M. T., Russell A. D. Triclosan and antibiotic resistance in Staphylococcus aureus. J Antimicrob Chemother. 2000 Jul;46(1):11–18. doi: 10.1093/jac/46.1.11. [DOI] [PubMed] [Google Scholar]
