Skip to main content
Infection and Immunity logoLink to Infection and Immunity
. 1985 Feb;47(2):575–578. doi: 10.1128/iai.47.2.575-578.1985

Highly toxinogenic but avirulent Park-Williams 8 strain of Corynebacterium diphtheriae does not produce siderophore.

L M Russell, R K Holmes
PMCID: PMC263213  PMID: 3155709

Abstract

The highly toxinogenic Park-Williams 8 strain of Corynebacterium diphtheriae grows slowly in vitro and is avirulent. C. diphtheriae Park-Williams 8 is defective in iron uptake and does not produce the corynebacterial siderophore corynebactin. Addition of partially purified corynebactin stimulated iron uptake and growth of iron-deprived C. diphtheriae Park-Williams 8 cells.

Full text

PDF
575

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BARDSDALE W. L., PAPPENHEIMER A. M., Jr Phage-host relationships in nontoxigenic and toxigenic diphtheria bacilli. J Bacteriol. 1954 Feb;67(2):220–232. doi: 10.1128/jb.67.2.220-232.1954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARKSDALE L., GARMISE L., HORIBATA K. Virulence, toxinogeny, and lysogeny in Corynebacterium diphtheriae. Ann N Y Acad Sci. 1960 Nov 21;88:1093–1108. doi: 10.1111/j.1749-6632.1960.tb20099.x. [DOI] [PubMed] [Google Scholar]
  3. BARKSDALE L., GARMISE L., RIVERA R. Toxinogeny in Corynebacterium diphtheriae. J Bacteriol. 1961 Apr;81:527–540. doi: 10.1128/jb.81.4.527-540.1961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Barksdale L. Corynebacterium diphtheriae and its relatives. Bacteriol Rev. 1970 Dec;34(4):378–422. doi: 10.1128/br.34.4.378-422.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cryz S. J., Jr, Russell L. M., Holmes R. K. Regulation of toxinogenesis in Corynebacterium diphtheriae: mutations in the bacterial genome that alter the effects of iron on toxin production. J Bacteriol. 1983 Apr;154(1):245–252. doi: 10.1128/jb.154.1.245-252.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Cryz S. J., Welkos S. L., Holmes R. K. Immunochemical studies of diphtherial toxin and related nontoxic mutant proteins. Infect Immun. 1980 Dec;30(3):835–846. doi: 10.1128/iai.30.3.835-846.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Finkelstein R. A., Sciortino C. V., McIntosh M. A. Role of iron in microbe-host interactions. Rev Infect Dis. 1983 Sep-Oct;5 (Suppl 4):S759–S777. doi: 10.1093/clinids/5.supplement_4.s759. [DOI] [PubMed] [Google Scholar]
  8. Gray C. H. The isolation of coproporphyrin III from Corynebacterium diphtheriae culture filtrates. Biochem J. 1948;43(2):191–193. [PMC free article] [PubMed] [Google Scholar]
  9. Kato M. Action of a toxic glycolipid of Corynebacterium diphtheriae on mitochondrial structure and function. J Bacteriol. 1970 Mar;101(3):709–716. doi: 10.1128/jb.101.3.709-716.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Payne S. M. Synthesis and utilization of siderophores by Shigella flexneri. J Bacteriol. 1980 Sep;143(3):1420–1424. doi: 10.1128/jb.143.3.1420-1424.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Russell L. M., Cryz S. J., Jr, Holmes R. K. Genetic and biochemical evidence for a siderophore-dependent iron transport system in Corynebacterium diphtheriae. Infect Immun. 1984 Jul;45(1):143–149. doi: 10.1128/iai.45.1.143-149.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Russell L. M., Holmes R. K. Initial characterization of the ferric iron transport system of Corynebacterium diphtheriae. J Bacteriol. 1983 Sep;155(3):1439–1442. doi: 10.1128/jb.155.3.1439-1442.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Weinberg E. D. Iron and infection. Microbiol Rev. 1978 Mar;42(1):45–66. doi: 10.1128/mr.42.1.45-66.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Welkos S. L., Holmes R. K. Characterization of a screening test for diphtherial toxin antigen produced by individual plaques of corynebacteriophages. J Clin Microbiol. 1979 Jun;9(6):693–698. doi: 10.1128/jcm.9.6.693-698.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Welkos S. L., Holmes R. K. Regulation of toxinogenesis in Corynebacterium diphtheriae. I. Mutations in bacteriophage beta that alter the effects of iron on toxin production. J Virol. 1981 Mar;37(3):936–945. doi: 10.1128/jvi.37.3.936-945.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Welkos S. L., Holmes R. K. Regulation of toxinogenesis in Corynebacterium diphtheriae. II. Genetic mapping of a tox regulatory mutation in bacteriophage beta. J Virol. 1981 Mar;37(3):946–954. doi: 10.1128/jvi.37.3.946-954.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES