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. 1984 Jul;45(1):56–61. doi: 10.1128/iai.45.1.56-61.1984

Influence of multiple genes on the magnitude of the antibody response to bacterial polysaccharide antigens.

P J Baker, J A Rudbach, B Prescott, G Caldes, C Evans, P W Stashak
PMCID: PMC263263  PMID: 6429050

Abstract

Studies conducted with F1 and F2 progeny of crosses between strains of inbred mice that differ greatly in their capacity to make an antibody response to type III pneumococcal polysaccharide, dextran B-1355, and lipopolysaccharide from Escherichia coli 0113 have shown that multiple genes influence the magnitude of the antibody response to these antigens. Other studies with hybrids derived from crosses between C3H/HeJ, CBA/N, and RIIIS/J mice have indicated that the genetic defects characteristic of these strains of mice are dissimilar and unlinked and that autosomal, as well as X-linked, genes control serum immunoglobulin M in unimmunized mice.

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Selected References

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