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. 1984 Aug;45(2):518–521. doi: 10.1128/iai.45.2.518-521.1984

Preparation of procoligenoids from Escherichia coli heat-labile enterotoxins.

R A Finkelstein, C V Sciortino, L C Rieke, M F Burks, M Boesman-Finkelstein
PMCID: PMC263278  PMID: 6378800

Abstract

Heat-labile enterotoxins from Escherichia coli strains of porcine and human origin polymerize on heating to form high-molecular-weight aggregates, "procoligenoids," analogous to procholeragenoid derived from the cholera enterotoxin. This aggregation is accompanied by loss of biological activity (toxicity). Further heating results in the release of B-subunit oligomers, coligenoids, analogous to choleragenoid. Further studies are needed to determine whether, like procholeragenoid, the procoligenoids are superior antigens in stimulating gut immunity after parenteral administration.

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Selected References

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