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. 1984 Jul;45(1):273–275. doi: 10.1128/iai.45.1.273-275.1984

A single gene determines rapid expulsion of Trichinella spiralis in mice.

R G Bell, L S Adams, R W Ogden
PMCID: PMC263312  PMID: 6429049

Abstract

In rats and some inbred mouse strains, one immune response, rapid expulsion, confers up to 95% protection against a challenge infection with Trichinella spiralis. Strain analysis in mice has shown that only three inbred strains, all originating from Swiss-line mice at the National Institutes of Health, Bethesda, Md., express rapid expulsion. Crosses between responder strain mice (NFR/N) and nonresponders (C3H/HeJ or B10 X BR) have indicated that rapid expulsion is dominant and autosomal (Bell et al., Exp. Parasitol. 53:301-314, 1982). In this study a segregation analysis of rapid expulsion in the F2 and backcross conformed to the Mendelian ratios expected of a single gene. This gene was not linked to the major histocompatibility complex (MHC) (chromosome 17) or the gene for albinism (c/c locus on chromosome 7). This locus has not previously been identified as conferring resistance to any infectious agent, and we have therefore designated the gene Ihe-1 (intestinal helminth expulsion 1).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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