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. 1984 Jul;45(1):293–296. doi: 10.1128/iai.45.1.293-296.1984

Immunobiologically active lipid A analogs synthesized according to a revised structural model of natural lipid A.

S Kotani, H Takada, M Tsujimoto, T Ogawa, K Harada, Y Mori, A Kawasaki, A Tanaka, S Nagao, S Tanaka, et al.
PMCID: PMC263318  PMID: 6735470

Abstract

Synthetic lipid A analogs which have two amide-bound and two ester-bound (R)-3-hydroxytetradecanoyl groups at the C-2 and -2' and C-3 and -3' positions of beta(1-6)glucosamine disaccharide mono- or diphosphates showed high activities in most in vitro assays, and the lethality of a diphosphate derivative to galactosamine-treated mice was almost comparable to that of natural lipid A. The pyrogenicity and Shwartzman induction activity of the synthetic analogs, however, were much less than those of natural lipid A.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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