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. 1984 Jan;43(1):402–406. doi: 10.1128/iai.43.1.402-406.1984

Antibodies to laminin in American cutaneous leishmaniasis.

J L Avila, M Rojas, M Rieber
PMCID: PMC263441  PMID: 6418660

Abstract

We found that serum samples from patients with different clinical forms of American cutaneous leishmaniasis (ACL) contained immunoglobulin G and immunoglobulin M antibodies which reacted with laminin but not with various other purified connective tissue components, such as collagen types I, III, IV, and V and fibronectin. Eighty-one percent of ACL patients had high antilaminin antibody levels, with a relationship existing between ACL ulcers and antibody levels. This was not, however, the case with patients having treated and healed ACL ulcers; only 34% of these patients had elevated antilaminin antibodies. Eighty-four percent of chronic Chagas' disease patients were also found to contain antilaminin antibodies that were limited to the immunoglobulin G class, but these were not detected in patients suffering from any of 11 other infectious diseases.

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Selected References

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