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. 1984 Jan;43(1):429–431. doi: 10.1128/iai.43.1.429-431.1984

Lyt phenotype and H-2 compatibility requirements of effector cells in the delayed-type hypersensitivity response to dengue virus infection.

T Pang, S Devi, W P Yeen, I F McKenzie, Y K Leong
PMCID: PMC263452  PMID: 6690413

Abstract

The nature of effector cells which mediate delayed-type hypersensitivity (DTH) to dengue type 2 virus and the influence of the H-2 complex on the cellular transfer of DTH was investigated. The DTH effector cells appeared to consist of two types of T cells, one Lyt-1.1+, the other Lyt-2.1+ or, alternatively, an interaction between these two T cell subsets may be required for maximal expression of DTH. Cellular transfer of DTH reactivity also required compatibility at the K and D or I region of the H-2 complex. Compatibility at the D region alone was not sufficient for transfer of DTH. The significance and implications of these findings are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ada G. L., Leung K. N., Ertl H. An analysis of effector T cell generation and function in mice exposed to influenza A or Sendai viruses. Immunol Rev. 1981;58:5–24. doi: 10.1111/j.1600-065x.1981.tb00347.x. [DOI] [PubMed] [Google Scholar]
  2. Benacerraf B., Germain R. N. A single major pathway of T-lymphocyte interactions in antigen-specific immune suppression. Scand J Immunol. 1981;13(1):1–10. doi: 10.1111/j.1365-3083.1981.tb00104.x. [DOI] [PubMed] [Google Scholar]
  3. Halstead S. B. Dengue haemorrhagic fever--a public health problem and a field for research. Bull World Health Organ. 1980;58(1):1–21. [PMC free article] [PubMed] [Google Scholar]
  4. Halstead S. B. The Alexander D. Langmuir Lecture. The pathogenesis of dengue. Molecular epidemiology in infectious disease. Am J Epidemiol. 1981 Nov;114(5):632–648. doi: 10.1093/oxfordjournals.aje.a113235. [DOI] [PubMed] [Google Scholar]
  5. Hogarth P. M., Edwards J., McKenzie I. F., Goding J. W., Liew F. Y. Monoclonal antibodies to the murine Ly-2.1 cell surface antigen. Immunology. 1982 May;46(1):135–144. [PMC free article] [PubMed] [Google Scholar]
  6. Hogarth P. M., Potter T. A., Cornell F. N., McLachlan R., McKenzie I. F. Monoclonal antibodies to murine cell surface antigens. I. Lyt-1.1. J Immunol. 1980 Oct;125(4):1618–1624. [PubMed] [Google Scholar]
  7. Huber B., Devinsky O., Gershon R. K., Cantor H. Cell-mediated immunity: delayed-type hypersensitivity and cytotoxic responses are mediated by different T-cell subclasses. J Exp Med. 1976 Jun 1;143(6):1534–1539. doi: 10.1084/jem.143.6.1534. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lu L. Y., Askonas B. A. Cross-reactivity for different type A influenza viruses of a cloned T-killer cell line. Nature. 1980 Nov 13;288(5787):164–165. doi: 10.1038/288164a0. [DOI] [PubMed] [Google Scholar]
  9. McDougal J. S., Shen F. W., Cort S. P., Bard J. Feedback suppression: phenotypes of T cell subsets involved in the Ly1 T cell-induced immunoregulatory circuit. J Immunol. 1980 Sep;125(3):1157–1160. [PubMed] [Google Scholar]
  10. McKenzie I. F., Potter T. Murine lymphocyte surface antigens. Adv Immunol. 1979;27:179–338. doi: 10.1016/s0065-2776(08)60263-1. [DOI] [PubMed] [Google Scholar]
  11. Nash A. A., Phelan J., Wildy P. Cell-mediated immunity in herpes simplex virus-infected mice: H-2 mapping of the delayed-type hypersensitivity response and the antiviral T cell response. J Immunol. 1981 Apr;126(4):1260–1262. [PubMed] [Google Scholar]
  12. Pang T. Delayed-type hypersensitivity: probable role in the pathogenesis of dengue hemorrhagic fever/dengue shock syndrome. Rev Infect Dis. 1983 Mar-Apr;5(2):346–352. doi: 10.1093/clinids/5.2.346. [DOI] [PubMed] [Google Scholar]
  13. Pang T., Wong P. Y., Pathmanathan R. Induction and characterization of delayed-type hypersensitivity to dengue virus in mice. J Infect Dis. 1982 Aug;146(2):235–242. doi: 10.1093/infdis/146.2.235. [DOI] [PubMed] [Google Scholar]
  14. Thomas D. B., Calderon R. A. T helper cells change their Lyt-1,2 phenotype during an immune response. Eur J Immunol. 1982 Jan;12(1):16–23. doi: 10.1002/eji.1830120106. [DOI] [PubMed] [Google Scholar]
  15. Vadas M. A., Miller J. F., McKenzie I. F., Chism S. E., Shen F. W., Boyse E. A., Gamble J. R., Whitelaw A. M. Ly and Ia antigen phenotypes of T cells involved in delayed-type hypersensitivity and in suppression. J Exp Med. 1976 Jul 1;144(1):10–19. doi: 10.1084/jem.144.1.10. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Weiner H. L., Greene M. I., Fields B. N. Delayed hypersensitivity in mice infected with reovirus. I. Identification of host and viral gene products responsible for the immune response. J Immunol. 1980 Jul;125(1):278–282. [PubMed] [Google Scholar]
  17. Zinkernagel R. M. H-2 restriction of virus-specific T-cell-mediated effector functions in vivo. II. Adoptive transfer of delayed-type hypersensitivity to murine lymphocytic choriomeningits virus is restriced by the K and D region of H-2. J Exp Med. 1976 Sep 1;144(3):776–787. doi: 10.1084/jem.144.3.776. [DOI] [PMC free article] [PubMed] [Google Scholar]

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