Skip to main content
NCBI home page
Infection and Immunity logoLink to Infection and Immunity
. 1984 Jan;43(1):435–437. doi: 10.1128/iai.43.1.435-437.1984

Hydroxyl Radical Scavengers Produce Similar Decreases in the Chemiluminescence Responses and Bactericidal Activities of Neutrophils

John E Repine 1,*, Kirsten Staehr Johansen 1, Elaine M Berger 1
PMCID: PMC263455  PMID: 6317572

Abstract

The addition of hydroxyl radical (·OH) scavengers caused similar decreases in the chemiluminescence responses and killing of Staphylococcus aureus 502A by human neutrophils in vitro.

Full text

PDF
435

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen R. C., Stjernholm R. L., Steele R. H. Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity. Biochem Biophys Res Commun. 1972 May 26;47(4):679–684. doi: 10.1016/0006-291x(72)90545-1. [DOI] [PubMed] [Google Scholar]
  2. Cheson B. D., Christensen R. L., Sperling R., Kohler B. E., Babior B. M. The origin of the chemiluminescence of phagocytosing granulocytes. J Clin Invest. 1976 Oct;58(4):789–796. doi: 10.1172/JCI108530. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cheung K., Archibald A. C., Robinson M. F. The origin of chemiluminescence produced by neutrophils stimulated by opsonized zymosan. J Immunol. 1983 May;130(5):2324–2329. [PubMed] [Google Scholar]
  4. Clawson C. C., Repine J. E. Quantitation of maximal bactericidal capability in human neutrophils. J Lab Clin Med. 1976 Aug;88(2):316–327. [PubMed] [Google Scholar]
  5. DeChatelet L. R., Long G. D., Shirley P. S., Bass D. A., Thomas M. J., Henderson F. W., Cohen M. S. Mechanism of the luminol-dependent chemiluminescence of human neutrophils. J Immunol. 1982 Oct;129(4):1589–1593. [PubMed] [Google Scholar]
  6. McPhail L. C., DeChatelet L. R., Johnston R. B., Jr Generation of chemiluminescence by a particulate fraction isolated from human neutrophils. Analysis of molecular events. J Clin Invest. 1979 Apr;63(4):648–655. doi: 10.1172/JCI109347. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Repine J. E., Clawson C. C., Friend P. S. Influence of a deficiency of the second component of complement on the bactericidal activity of neutrophils in vitro. J Clin Invest. 1977 May;59(5):802–809. doi: 10.1172/JCI108702. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Repine J. E., Eaton J. W., Anders M. W., Hoidal J. R., Fox R. B. Generation of hydroxyl radical by enzymes, chemicals, and human phagocytes in vitro. Detection with the anti-inflammatory agent, dimethyl sulfoxide. J Clin Invest. 1979 Dec;64(6):1642–1651. doi: 10.1172/JCI109626. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Repine J. E., Fox R. B., Berger E. M. Hydrogen peroxide kills Staphylococcus aureus by reacting with staphylococcal iron to form hydroxyl radical. J Biol Chem. 1981 Jul 25;256(14):7094–7096. [PubMed] [Google Scholar]
  10. Repine J. E., White J. G., Clawson C. C., Holmes B. M. Effects of phorbol myristate acetate on the metabolism and ultrastructure of neutrophils in chronic granulomatous disease. J Clin Invest. 1974 Jul;54(1):83–90. doi: 10.1172/JCI107752. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Root R. K., Cohen M. S. The microbicidal mechanisms of human neutrophils and eosinophils. Rev Infect Dis. 1981 May-Jun;3(3):565–598. doi: 10.1093/clinids/3.3.565. [DOI] [PubMed] [Google Scholar]
  12. Rosen H., Klebanoff S. J. Chemiluminescence and superoxide production by myeloperoxidase-deficient leukocytes. J Clin Invest. 1976 Jul;58(1):50–60. doi: 10.1172/JCI108458. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Stevens P., Winston D. J., Van Dyke K. In vitro evaluation of opsonic and cellular granulocyte function by luminol-dependent chemiluminescence: utility in patients with severe neutropenia and cellular deficiency states. Infect Immun. 1978 Oct;22(1):41–51. doi: 10.1128/iai.22.1.41-51.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES